Gene: SKAP2
Official Full Name: src kinase associated phosphoprotein 2provided by HGNC
Gene Summary: The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33722 | SKAP2 Knockout cell line (HeLa) | Human | SKAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO33723 | SKAP2 Knockout cell line (HCT 116) | Human | SKAP2 | 1:2~1:4 | Negative | Online Inquiry |
KO33724 | SKAP2 Knockout cell line (HEK293) | Human | SKAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO33725 | SKAP2 Knockout cell line (A549) | Human | SKAP2 | 1:3~1:4 | Negative | Online Inquiry |
SKAP2 Gene Knockout Cell Lines represent a pivotal advancement in the study of immune responses and cellular signaling pathways. These cell lines are genetically engineered to have a complete knockout of the SKAP2 (Src Kinase Associated Protein 2) gene, which plays a crucial role in T-cell receptor signaling and the activation of various immune cells. By disrupting the SKAP2 gene's function, researchers can meticulously explore its implications in cellular communication, signal transduction, and the overall immune system functionality.
The key mechanisms behind the utility of SKAP2 Gene Knockout Cell Lines involve the investigation of how the absence of this protein affects immune cell activation, maturation, and differentiation. By utilizing these cell lines, researchers can conduct assays that elucidate the downstream effects of SKAP2 deficiency, contributing to a deeper understanding of immune-related pathologies. This specificity opens avenues for therapeutic interventions targeting immune dysfunctions, autoimmune diseases, and potentially even cancer immunotherapy.
The scientific importance of these cell lines extends into various applications within both research and clinical settings. For instance, they serve as critical tools in drug development and testing to assess the efficacy of new immunotherapies. Moreover, their relevance in basic research makes them invaluable for elucidating fundamental principles of cellular signal transduction.
What sets SKAP2 Gene Knockout Cell Lines apart from alternative models is their precise genetic modification, creating a reliable and reproducible platform for immune research. Unlike other models that may only partially mimic the absence of specific genes, these knockout lines allow for unequivocal insights into the functional consequences of SKAP2 absence.
For researchers and clinicians invested in advancing the understanding of immune mechanisms and developing novel therapeutic strategies, SKAP2 Gene Knockout Cell Lines offer unparalleled value. They provide a robust, controlled environment to dissect complex signaling pathways and can significantly aid in hypothesis-driven research.
Our company prides itself on its commitment to advancing biological science through high-quality, innovative products. With expertise in developing genetically modified cell lines, we continue to support researchers in unlocking new scientific insights that drive progress in immunology and beyond.
Please note that all services are for research use only. Not intended for any clinical use.
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