Gene: SIM1
Official Full Name: SIM bHLH transcription factor 1provided by HGNC
Gene Summary: SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35432 | SIM1 Knockout cell line (HEK293) | Human | SIM1 | 1:3~1:6 | Negative | Online Inquiry |
SIM1 Gene Knockout Cell Lines represent an advanced biological tool designed for researchers studying the functional roles of the SIM1 gene—a critical regulator of neuronal development and energy homeostasis. These cell lines are specifically engineered to contain a complete deletion of the SIM1 gene, providing a unique model for investigating the downstream effects of its absence in cellular signaling, metabolic pathways, and neurobiological processes.
The primary function of SIM1 Gene Knockout Cell Lines derives from their ability to facilitate the dissection of gene function and pathway interactions. By utilizing CRISPR-Cas9 genome editing technology, these cell lines enable scientists to observe phenotypic and molecular changes associated with SIM1 deletion. This mechanism allows for a more comprehensive understanding of how altered gene expression can impact cellular behavior, making it invaluable for exploring conditions such as obesity, diabetes, and neurodevelopmental disorders.
The scientific importance of these cell lines extends to both basic and applied research. In clinical settings, they serve as essential models for drug discovery and testing, where understanding gene function can lead to the development of targeted therapies. As a result, they are integral to identifying potential biomarkers and treatment strategies for metabolic and neurological diseases.
In terms of advantages, SIM1 Gene Knockout Cell Lines stand out due to their high specificity and reliability. Unlike traditional knockdown methods, which may produce incomplete or off-target effects, the complete gene knockout achieved through CRISPR ensures robust results that are reproducible across experiments. This level of precision provides researchers with confidence in their findings and is particularly advantageous when investigating complex biological systems.
For researchers and clinicians, the ability to utilize a ready-to-use cell line that accurately models gene knockout scenarios significantly accelerates research timelines and enhances the potential for impactful discoveries. As an organization dedicated to advancing life sciences, our expertise in developing innovative biological products ensures that our SIM1 Gene Knockout Cell Lines meet the highest standards of quality and are a reliable resource for your research endeavors. Our commitment to scientific excellence and customer support empowers you to push the boundaries of biological research.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.