Gene: SIGLEC10
Official Full Name: sialic acid binding Ig like lectin 10provided by HGNC
Gene Summary: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09935 | SIGLEC10 Knockout cell line (HEK293) | Human | SIGLEC10 | 1:3~1:6 | Negative | Online Inquiry |
SIGLEC10 Gene Knockout Cell Lines are specially engineered cell lines designed to facilitate the study of the SIGLEC10 gene, which encodes a sialic acid-binding immunoglobulin-like lectin involved in modulating immune responses. These knockout cell lines provide researchers with a unique tool to investigate the biological role of SIGLEC10 in various cellular processes, particularly in the context of immune function and inflammation.
The primary mechanism by which these cell lines operate involves the complete disruption of the SIGLEC10 gene, leading to the absence of functional SIGLEC10 protein. This allows for rigorous examination of its physiological roles, such as its contributions to immune evasion by pathogens and the regulation of macrophage activity. Researchers can use these cell lines to elucidate the molecular pathways influenced by SIGLEC10 and investigate how its knockout affects cellular behaviors such as proliferation, apoptosis, and cytokine production.
The scientific importance of SIGLEC10 Gene Knockout Cell Lines extends across several fields, including immunology, oncology, and translational medicine. They are particularly valuable for the development of therapies targeting SIGLEC10, providing an avenue for potential treatments related to autoimmune diseases, cancer immunotherapy, and enhancing vaccine efficacy. In clinical settings, understanding the role of SIGLEC10 could lead to breakthroughs in managing diseases where immune regulation is crucial.
Compared to conventional cell lines or systems that only modulate SIGLEC10 function pharmacologically, the knockout cell lines offer an unprecedented ability to study the long-term effects of the gene's absence. This allows researchers to observe more profound and specific phenotypic changes without the confounding effects of transient inhibition or external compounds.
For researchers, clinicians, and pharmaceutical developers, our SIGLEC10 Gene Knockout Cell Lines represent an essential resource for advancing our understanding of immune mechanisms. By utilizing these models, users gain insights that drive innovation in therapeutic discovery and development. Our company, with extensive expertise in generating specialized genetic models, is committed to providing high-quality biological products that empower scientific research and enhance clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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