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SH2B1 Knockout Cell Lines

Gene: SH2B1

Official Full Name: SH2B adaptor protein 1provided by HGNC

Gene Summary: This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28531 SH2B1 Knockout cell line (HeLa) Human SH2B1 1:3~1:6 Negative Online Inquiry
KO28532 SH2B1 Knockout cell line (HCT 116) Human SH2B1 1:2~1:4 Negative Online Inquiry
KO28533 SH2B1 Knockout cell line (HEK293) Human SH2B1 1:3~1:6 Negative Online Inquiry
KO28534 SH2B1 Knockout cell line (A549) Human SH2B1 1:3~1:4 Negative Online Inquiry

Background

SH2B1 Gene Knockout Cell Lines are advanced biological models designed to facilitate in-depth research into the function and regulation of the SH2B1 gene, known for its role in cellular signaling pathways that influence growth, metabolism, and differentiation. These specialized cell lines feature a precise knockout of the SH2B1 gene, created using cutting-edge CRISPR/Cas9 technology, allowing researchers to explore the gene’s contribution to various physiological processes and disease states.

The primary function of the SH2B1 Gene Knockout Cell Lines is to serve as a tool for understanding the molecular mechanisms underlying SH2B1-mediated signaling pathways. By analyzing these knockout models, researchers can dissect the effects of SH2B1 depletion on cellular behavior, including changes in insulin signaling, synaptic plasticity, and metabolic homeostasis. This model system fosters insights into a range of diseases such as obesity, diabetes, and neurodegenerative disorders, wherein SH2B1 is believed to play a critical role.

In both research and clinical settings, the ability to study gene function using knockout cell lines provides invaluable data for drug discovery and the development of targeted therapies. Compared to alternative models, such as overexpression systems or wild-type cells, SH2B1 Gene Knockout Cell Lines allow for more straightforward interpretation of the gene’s loss-of-function effects, leading to clearer observation of physiological implications.

The unique selling point of our SH2B1 Gene Knockout Cell Lines lies in their customization and reliability, validated through rigorous quality control and characterization processes. They are ready-to-use, minimizing the time researchers spend on establishing models, thus accelerating the pace of discovery.

These cell lines are indispensable for researchers and clinicians aiming to deepen their understanding of SH2B1's role in health and disease, providing a robust platform to drive innovative therapeutic developments. Our company brings years of expertise in genetic engineering and cell line development, ensuring that our products meet the highest standards of scientific accuracy and reliability, empowering your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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