Gene: SGMS2
Official Full Name: sphingomyelin synthase 2provided by HGNC
Gene Summary: Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00495 | SGMS2 gRNA3-gRNA4 KO plasmid | SGMS2 | $850 | |||
GP00512 | SGMS2 gRNA1-gRNA2 KO plasmid | SGMS2 | $850 | |||
KO00780 | SGMS2 Knockout cell line(Hep G2) | Human | SGMS2 | 1:2~1:4 | Negative | Online Inquiry |
KO00983 | SGMS2 Knockout cell line (NCI-H1299) | Human | SGMS2 | 1:2~1:3 | Negative | Online Inquiry |
KO00993 | SGMS2 Knockout cell line (A549) | Human | SGMS2 | 1:3~1:4 | Negative | Online Inquiry |
KO07650 | SGMS2 Knockout cell line (HeLa) | Human | SGMS2 | 1:3~1:6 | Negative | Online Inquiry |
KO07651 | SGMS2 Knockout cell line (HCT 116) | Human | SGMS2 | 1:2~1:4 | Negative | Online Inquiry |
KO07652 | SGMS2 Knockout cell line (HEK293) | Human | SGMS2 | 1:3~1:6 | Negative | Online Inquiry |
SGMS2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disrupt the SGMS2 gene, which encodes for sphingomyelin synthase 2, an enzyme implicated in sphingolipid metabolism and cellular signaling pathways. These cell lines facilitate the investigation of the functional role of SGMS2 in various biological processes, including apoptosis, proliferation, and inflammation, by providing a model system where the gene is completely inactivated.
The key function of SGMS2 Gene Knockout Cell Lines lies in their ability to help researchers elucidate the mechanistic pathways influenced by sphingomyelin and its derivatives. By using these knockout lines, scientists can study alternative compensatory mechanisms that may arise in response to the loss of SGMS2, offering valuable insights into metabolic reprogramming and cellular responses in health and disease states. This is particularly relevant in studies examining metabolic disorders, cancer, and neurodegenerative diseases, where sphingolipid metabolism often plays a critical role.
The scientific importance of SGMS2 knockouts is underscored by their applications in drug development and therapeutic strategies. Understanding the role of SGMS2 can inform the design of new interventions targeting sphingolipid profiles, providing avenues for developing novel treatments. Moreover, these cell lines are an essential resource for researchers investigating cellular signaling pathways and their implications in disease mechanisms.
One of the product's unique selling points is the high efficiency of gene knockout achieved with our proprietary CRISPR/Cas9 technology, ensuring that researchers receive reliable and reproducible results. Unlike competing products, which may only partially disrupt gene function or yield inconsistent phenotypes, our SGMS2 Gene Knockout Cell Lines provide robust models that enable clear conclusions to be drawn from experimental data.
For researchers and clinicians alike, the value of SGMS2 Gene Knockout Cell Lines is manifested in their ability to accelerate discoveries that could lead to groundbreaking advancements in understanding and treating diseases linked to sphingolipid metabolism. By providing a state-of-the-art tool, we empower scientists to translate their findings into clinical applications effectively.
As a company committed to excellence in synthetic biology and genetic engineering, we strive to provide products that facilitate cutting-edge research and innovation. Our expertise in biomanufacturing and gene editing ensures our offerings are not only of the highest quality but also tailored to meet the needs of a rapidly evolving scientific landscape.
Please note that all services are for research use only. Not intended for any clinical use.
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