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SGCD Knockout Cell Lines

Gene: SGCD

Official Full Name: sarcoglycan deltaprovided by HGNC

Gene Summary: The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02948 SGCD Knockout cell line (A549) Human SGCD 1:3~1:4 Negative Online Inquiry

Background

SGCD Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the SGCD gene, which encodes for the protein gamma-sarcoglycan, a vital component of the dystrophin-glycoprotein complex in muscle tissue. These cell lines have been engineered using advanced CRISPR/Cas9 technology to create precise deletions of the SGCD gene, enabling researchers to examine the biological consequences of gene deficiency on cellular function and muscle pathology.

The primary function of SGCD Gene Knockout Cell Lines is to serve as a powerful tool in elucidating the pathophysiology of muscle disorders, particularly those related to the dystrophin complex, such as Limb-Girdle Muscular Dystrophy. By removing the SGCD gene, these cell lines mimic the molecular and cellular mechanisms seen in disease states, allowing for detailed studies on muscle cell behavior, signaling pathways, and potential therapeutic interventions.

The scientific importance of these cell lines cannot be overstated; they represent a breakthrough in muscular dystrophy research, enabling high-throughput drug screening, gene therapy investigations, and the discovery of novel biomarkers for disease progression. Their application in both laboratory and clinical settings enhances our understanding of muscle disease mechanisms and aids in the development of targeted treatments.

Compared to traditional models, SGCD Gene Knockout Cell Lines offer unique advantages such as specificity and reproducibility, minimizing off-target effects often associated with earlier gene-editing techniques. Their ability to closely simulate human disease also provides a more relevant biological context for drug efficacy and toxicity studies.

Researchers and clinicians will find significant value in the use of SGCD Gene Knockout Cell Lines as they advance not only fundamental biological knowledge but also pave the way for innovative therapeutic approaches. Our company specializes in producing high-quality biological products and cell lines, ensuring that every product, including the SGCD Gene Knockout Cell Lines, adheres to the highest standards of scientific integrity and quality, thereby fostering the advancement of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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