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SETD5 Knockout Cell Lines

Gene: SETD5

Official Full Name: SET domain containing 5provided by HGNC

Gene Summary: This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14191 SETD5 Knockout cell line (HeLa) Human SETD5 1:3~1:6 Negative Online Inquiry
KO14192 SETD5 Knockout cell line (HCT 116) Human SETD5 1:2~1:4 Negative Online Inquiry
KO14193 SETD5 Knockout cell line (HEK293) Human SETD5 1:3~1:6 Negative Online Inquiry
KO14194 SETD5 Knockout cell line (A549) Human SETD5 1:3~1:4 Negative Online Inquiry

Background

SETD5 Gene Knockout Cell Lines represent a crucial tool in genetic research, specifically designed for the functional analysis of the SETD5 gene, known for its role in neurodevelopmental processes and gene regulation. These cell lines are engineered to knock out the SETD5 gene, creating a model that mimics the gene's loss-of-function mutations found in various disorders, providing researchers with a systematic approach to studying the gene's biological roles.

The primary mechanism at play within these knockout cell lines involves the complete deletion of the SETD5 sequence, achieved using advanced CRISPR/Cas9 technology. This precision editing allows for the investigation of downstream effects on cellular pathways, gene expression, and phenotypic changes, facilitating an in-depth understanding of how SETD5 mutations contribute to disease pathology. Researchers can utilize these cell lines in functional assays, drug screening, and the exploration of gene-environment interactions, thereby advancing knowledge in both developmental biology and clinical genomics.

The scientific importance of SETD5 Gene Knockout Cell Lines cannot be overstated, as they are foundational in translational research aimed at elucidating the mechanisms underlying neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. Compared to traditional models, these knockout cell lines offer higher specificity, reproducibility, and relevance, allowing for greater confidence in research outcomes.

Furthermore, SETD5 Gene Knockout Cell Lines provide unique advantages such as ease of use in routine laboratory settings, cost-effectiveness for large-scale studies, and robust data generation potential that minimizes variability. By offering tailored solutions for the study of gene functions, these cell lines can significantly contribute to the identification of potential therapeutic targets and biomarkers.

For researchers and clinicians focused on gene function, disease modeling, and therapeutic development, SETD5 Gene Knockout Cell Lines are invaluable assets that enhance experimental designs and data interpretation. Our company brings years of expertise in genetic engineering and cell line development, ensuring that customers receive not only high-quality products but also comprehensive support in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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