Home / SERPINF1 Knockout Cell Lines

SERPINF1 Knockout Cell Lines

Gene: SERPINF1

Official Full Name: serpin family F member 1provided by HGNC

Gene Summary: This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11669 SERPINF1 Knockout cell line (HeLa) Human SERPINF1 1:3~1:6 Negative Online Inquiry
KO11670 SERPINF1 Knockout cell line (HCT 116) Human SERPINF1 1:2~1:4 Negative Online Inquiry
KO11671 SERPINF1 Knockout cell line (HEK293) Human SERPINF1 1:3~1:6 Negative Online Inquiry
KO11672 SERPINF1 Knockout cell line (A549) Human SERPINF1 1:3~1:4 Negative Online Inquiry

Background

SERPINF1 Gene Knockout Cell Lines represent a crucial tool for researchers and clinicians engaged in the exploration of cellular and molecular biology related to serpins, specifically the SERPINF1 gene, which encodes the protein pigment epithelium-derived factor (PEDF). These knockout cell lines are expertly engineered to ablate the expression of the SERPINF1 gene, thereby enabling the study of its functional roles and implications in various pathological conditions, including cancer, age-related macular degeneration, and neurodegenerative diseases.

The mechanisms by which these gene knockout cell lines operate hinge on CRISPR/Cas9 technology or other gene-editing techniques which result in the targeted disruption of the SERPINF1 gene. By studying the resultant phenotypic changes, scientists can elucidate the biological pathways involving PEDF, enhancing our understanding of its regulatory roles in cell survival, apoptosis, and angiogenesis.

The scientific importance of these knockout cell lines is reflected in their diverse applications in both fundamental and applied research. They facilitate investigations into the mechanisms of disease progression and aid in the identification of potential therapeutic targets, making them invaluable in drug discovery and developmental studies. Clinically, they hold promise for advancing personalized medicine strategies, as understanding SERPINF1 function may contribute to tailored treatment approaches for related disorders.

What sets SERPINF1 Gene Knockout Cell Lines apart from alternatives is their reliability and specificity in gene disruption. These lines provide a consistent model system for reproducible results, crucial for high-quality scientific investigation. Unlike other approaches that may leave residual expression or have off-target effects, our knockout lines ensure complete abrogation of the SERPINF1 gene, offering clear insights into gene function.

Researchers and clinicians can greatly benefit from leveraging SERPINF1 Gene Knockout Cell Lines to accelerate their studies and achieve their objectives with confidence. By utilizing this sophisticated tool, they can deepen their understanding of disease mechanisms and uncover novel therapeutic avenues, ultimately impacting patient care positively.

Our company prides itself on its commitment to excellence in providing high-quality biological products. With extensive experience in the development of knockout cell lines and a dedication to advancing scientific research, we ensure that our offerings meet the rigorous demands of modern biology and contribute meaningfully to the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.