Gene: SERAC1
Official Full Name: serine active site containing 1provided by HGNC
Gene Summary: The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24421 | SERAC1 Knockout cell line (HeLa) | Human | SERAC1 | 1:3~1:6 | Negative | Online Inquiry |
KO24422 | SERAC1 Knockout cell line (HCT 116) | Human | SERAC1 | 1:2~1:4 | Negative | Online Inquiry |
KO24423 | SERAC1 Knockout cell line (HEK293) | Human | SERAC1 | 1:3~1:6 | Negative | Online Inquiry |
KO24424 | SERAC1 Knockout cell line (A549) | Human | SERAC1 | 1:3~1:4 | Negative | Online Inquiry |
SERAC1 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the SERAC1 gene, which has been implicated in various human diseases, particularly those affecting mitochondrial function. These cell lines are generated using advanced CRISPR-Cas9 technology to delete specific sequences of the SERAC1 gene, resulting in a complete loss of function. This knockout approach allows researchers to investigate the gene's role in cellular processes such as lipid metabolism, mitochondrial dynamics, and autophagy, providing valuable insights into the underlying mechanisms of pathology associated with SERAC1 deficiency.
The key function of SERAC1 Gene Knockout Cell Lines lies in their ability to mimic the genetic and functional deficits observed in patients with SERAC1-related disorders. By utilizing these cell lines, scientists can conduct experiments to comprehend how the absence of SERAC1 affects cellular physiology and contributes to disease phenotypes, facilitating the exploration of potential therapeutic pathways.
In terms of scientific importance, SERAC1 Gene Knockout Cell Lines serve as a critical tool in both research and clinical settings. They enable the testing of novel drugs or gene therapies targeting SERAC1-associated conditions, thereby accelerating the transition from bench to bedside. The insights derived from studies using these cell lines can contribute significantly to the development of targeted interventions, enhancing treatment options for patients.
Compared to alternative models such as wild-type cell lines, SERAC1 Gene Knockout Cell Lines offer a unique advantage by providing a direct depiction of SERAC1's cellular functions. This specificity allows for more accurate modeling of the disease state, yielding results that are more reflective of in vivo conditions than non-targeted models. Furthermore, the reproducibility and reliability of experiments conducted using these engineered cells reduce variability in research outcomes, leading to more robust data.
For researchers, clinicians, and pharmaceutical companies, SERAC1 Gene Knockout Cell Lines represent a valuable resource that can bridge the gap between basic science and clinical application. Their unique capabilities make them invaluable in shedding light on the complex biology of SERAC1-related diseases and facilitating the development of innovative therapies.
Our company specializes in providing high-quality genetically modified cellular models tailored to meet the specific needs of the research community. With advanced techniques and a commitment to precision, we ensure that our products, such as SERAC1 Gene Knockout Cell Lines, empower researchers to unlock novel insights in biological research and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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