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SEPTIN6 Knockout Cell Lines

Gene: SEPTIN6

Official Full Name: septin 6provided by HGNC

Gene Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29781 SEPTIN6 Knockout cell line (HeLa) Human SEPTIN6 1:3~1:6 Negative Online Inquiry
KO29782 SEPTIN6 Knockout cell line (HCT 116) Human SEPTIN6 1:2~1:4 Negative Online Inquiry
KO29783 SEPTIN6 Knockout cell line (HEK293) Human SEPTIN6 1:3~1:6 Negative Online Inquiry
KO29784 SEPTIN6 Knockout cell line (A549) Human SEPTIN6 1:3~1:4 Negative Online Inquiry

Background

SEPTIN6 Gene Knockout Cell Lines are genetically engineered cell lines characterized by the targeted disruption of the SEPTIN6 gene, a member of the septin family of GTP-binding proteins. These cell lines serve as a robust tool for studying the functional roles of SEPTIN6 in cellular processes such as cytoskeletal dynamics, cell division, and signal transduction. The knockout of this gene allows researchers to investigate the consequences of losing SEPTIN6 expression, providing insights into its potential involvement in various pathological conditions.

The primary mechanism of action for these knockout cell lines lies in the absence of SEPTIN6 protein, which contributes to the architecture of the cytoskeleton and influences cellular organization. By utilizing these cells, researchers can elucidate the role of SEPTIN6 in cytokinesis and its potential regulatory functions in cancer biology, neurobiology, and developmental processes. This research is critical for the development of targeted therapies and the understanding of disease mechanisms.

SEPTIN6 Gene Knockout Cell Lines hold significant scientific importance as they offer a unique platform for investigating the biological functions of septins and their implications in diseases. Compared to alternative models, our cell lines provide a highly specific and controlled genetic background, ensuring reliable and reproducible results, which are essential in translational research and drug discovery.

For researchers and clinicians, the value of these knockout cell lines lies in their ability to facilitate groundbreaking investigations into gene function and disease mechanisms. Their use can lead to novel insights and therapeutic strategies that may improve clinical outcomes for patients suffering from septin-related disorders.

Drawing upon our extensive expertise in gene editing technologies and cellular biology, we are committed to providing high-quality biological products that support the scientific community in their quest for knowledge and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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