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SEPTIN4 Knockout Cell Lines

Gene: SEPTIN4

Official Full Name: septin 4provided by HGNC

Gene Summary: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35985 SEPTIN4 Knockout cell line (HCT 116) Human SEPTIN4 1:2~1:4 Negative Online Inquiry
KO35986 SEPTIN4 Knockout cell line (HEK293) Human SEPTIN4 1:3~1:6 Negative Online Inquiry

Background

SEPTIN4 Gene Knockout Cell Lines are genetically modified cellular models designed to facilitate the study of the septin 4 gene's role in cellular processes. These cell lines feature a targeted knockout of the SEPTIN4 gene, leading to the disruption of its normal function, which is crucial for cytokinesis, cytoskeletal organization, and membrane dynamics. By utilizing CRISPR-Cas9 or other gene-editing technologies, these cell lines provide a precise and reproducible method for examining the gene’s involvement in various biological pathways.

The primary function of SEPTIN4 involves its assembly into hetero-oligomeric complexes, which play a pivotal role in the maintenance of cell shape and the regulation of exocytosis and endocytosis. Thus, these knockout cell lines are invaluable for researchers who need to explore aberrations in these processes linked to diseases such as cancer, where cell division and migration are significantly altered. Moreover, the SEPTIN4 knockout models aid in identifying potential therapeutic targets by elucidating the molecular mechanisms underlying pathologies associated with its dysregulation.

From a scientific standpoint, the use of these cell lines offers distinct advantages over traditional methods, including enhanced specificity in studies due to the exact genetic alteration and the ability to model human disease phenotypes more accurately. Unlike other alternatives, SEPTIN4 Gene Knockout Cell Lines can provide insights into functional interactions with other proteins, contributing to a deeper understanding of the cellular mechanisms involved.

For researchers and clinicians seeking to explore the intersection of genetics and cell biology, this product serves as a critical tool for advancing knowledge in the field. It allows for the effective investigation of therapeutics targeting septin-related pathways and supports broader research agendas in oncology and developmental biology.

Our company specializes in providing high-quality genetic models and cell line development services, ensuring that our products, including SEPTIN4 Gene Knockout Cell Lines, meet the rigorous demands of contemporary biological research. With a commitment to excellence, we empower scientists to discover and innovate and advance their work with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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