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SENP1 Knockout Cell Lines

Gene: Senp1

Gene Summary: Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09786 SENP1 Knockout cell line (HeLa) Human SENP1 1:3~1:6 Negative Online Inquiry
KO09787 SENP1 Knockout cell line (HCT 116) Human SENP1 1:2~1:4 Negative Online Inquiry
KO09788 SENP1 Knockout cell line (HEK293) Human SENP1 1:3~1:6 Negative Online Inquiry
KO09789 SENP1 Knockout cell line (A549) Human SENP1 1:3~1:4 Negative Online Inquiry

Background

Senp1 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the Senp1 gene, a critical regulator of SUMOylation, a post-translational modification which modulates protein function and stability. These cell lines serve as vital tools for scientists studying the role of SUMOylation in various biological processes, including cell signaling, apoptosis, and the regulation of gene expression. The targeted knockout of the Senp1 gene enables researchers to investigate the downstream effects of disrupted SUMOylation pathways, providing insights into cellular mechanisms and disease processes.

The primary function of Senp1 involves the deconjugation of SUMO proteins from their target substrates, thereby influencing protein stability, localization, and activity. By utilizing Senp1 Gene Knockout Cell Lines, researchers can discern how the lack of this specific SUMO protease alters cellular physiology, which is essential for understanding various pathological states, including cancer and neurodegenerative disorders.

In clinical and research settings, these cell lines are indispensable for investigating therapeutic targets and biomarkers for diseases where SUMOylation plays a critical role. They allow for high-throughput screening of potential compounds that can modulate the SUMOylation process and thus provide insights into innovative therapeutic approaches.

One of the unique selling points of our Senp1 Gene Knockout Cell Lines is their robustness and reproducibility across experiments, which enhances the reliability of results compared to alternative models. Additionally, these cell lines come with extensive characterization data, ensuring that researchers can trust their performance in different applications.

The value of Senp1 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking discoveries. For researchers and clinicians alike, the capacity to manipulate SUMOylation pathways holds promise for developing novel therapies with precision targeting of disease mechanisms.

Our company prides itself on its expertise in developing high-quality biological products, supporting the scientific community with reliable tools for advancing research and clinical applications. Our Senp1 Gene Knockout Cell Lines are a testament to our commitment to excellence in enabling scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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