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SEMA3E Knockout Cell Lines

Gene: SEMA3E

Official Full Name: semaphorin 3Eprovided by HGNC

Gene Summary: Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32873 SEMA3E Knockout cell line (HCT 116) Human SEMA3E 1:2~1:4 Negative Online Inquiry
KO32874 SEMA3E Knockout cell line (HEK293) Human SEMA3E 1:3~1:6 Negative Online Inquiry
KO32875 SEMA3E Knockout cell line (A549) Human SEMA3E 1:3~1:4 Negative Online Inquiry

Background

SEMA3E Gene Knockout Cell Lines are specialized cellular models that have been engineered through CRISPR/Cas9 technology to lack the expression of the SEMA3E gene. Semaphorin 3E (SEMA3E) is a critical regulator of neuronal development, axon guidance, and angiogenesis. The knockout of this gene elucidates the cellular responses that result from the absence of its signaling pathways, allowing researchers to explore the roles of SEMA3E in both physiological and pathological states.

These cell lines utilize enhanced mechanisms to study SEMA3E-associated pathways in depth. By eliminating the SEMA3E function, researchers can investigate downstream signaling cascades, evaluate cellular interactions in the absence of these cues, and assess how this deficiency affects cell migration, proliferation, and differentiation. This targeted approach provides invaluable insights into conditions such as cancer metastasis, neurodegenerative disorders, and embryonic development.

The scientific significance of SEMA3E Gene Knockout Cell Lines is considerable, serving as vital tools in fundamental and applied research. They enable the investigation of gene function and its molecular implications in a controlled environment, fostering advancements in therapeutic strategies. Additionally, these cell lines are essential for validating potential drug targets and understanding resistance mechanisms in cancer treatments.

What sets our SEMA3E Gene Knockout Cell Lines apart is their robust and reproducible performance. Unlike other gene knockout models which may exhibit off-target effects or inconsistencies, our meticulously validated lines offer reliability and specificity. Their ease of use in standard laboratory setups allows researchers to focus on findings rather than troubleshooting, ultimately expediting the research process.

For researchers and clinicians alike, our SEMA3E Gene Knockout Cell Lines represent a valuable asset in the landscape of biomedical research. Their capacity to enhance understanding of complex biological processes can lead to breakthroughs in treatment strategies and disease management. Our company is committed to providing high-quality biological products backed by extensive expertise in genetic engineering and cell line development, ensuring that our customers have access to the best tools for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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