Gene: SEMA3C
Official Full Name: semaphorin 3Cprovided by HGNC
Gene Summary: This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00443 | SEMA3C Knockout cell line (A549) | Human | SEMA3C | 1:3~1:4 | Negative | Online Inquiry |
KO31776 | SEMA3C Knockout cell line (HeLa) | Human | SEMA3C | 1:3~1:6 | Negative | Online Inquiry |
KO31777 | SEMA3C Knockout cell line (HCT 116) | Human | SEMA3C | 1:2~1:4 | Negative | Online Inquiry |
KO31778 | SEMA3C Knockout cell line (HEK293) | Human | SEMA3C | 1:3~1:6 | Negative | Online Inquiry |
SEMA3C Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the Semaphorin 3C (SEMA3C) gene, which encodes a protein that plays a significant role in various biological processes such as neuronal development, angiogenesis, and immune modulation. By employing CRISPR-Cas9 gene editing technology, these knockout cell lines effectively disable the SEMA3C gene, providing researchers with a valuable tool for investigating the downstream effects of SEMA3C loss on cellular function and behavior.
The key function of SEMA3C is its involvement in the regulation of axonal guidance and neuronal connectivity through its interaction with neuropilin and plexin receptors. Understanding the mechanisms by which SEMA3C influences these processes is pivotal, as dysregulation has been implicated in various neurodevelopmental disorders, cancer metastasis, and cardiovascular diseases. Through the use of these knockout cell lines, researchers can explore the implications of SEMA3C absence in specific pathological contexts, thus advancing the knowledge of its role in health and disease.
The scientific importance of SEMA3C Gene Knockout Cell Lines extends beyond basic research; they have notable applications in drug discovery and development, particularly for therapeutic interventions targeting neuronal and vascular diseases. By utilizing these models, scientists can screen for compounds that modulate the effects of SEMA3C, enabling more effective therapeutic strategies tailored to specific conditions.
One distinct advantage of our SEMA3C Gene Knockout Cell Lines is their robustness and ease of use, offering a reliable alternative to traditional gene knockdown techniques that may not provide complete functional disruption. Additionally, their reproducibility ensures that results are consistent across experiments, an essential factor for high-impact research. The targeted nature of these knockout lines allows for precise experimental designs, enabling researchers to elucidate the cellular pathways influenced by SEMA3C with confidence.
For researchers and clinicians looking to deepen their understanding of SEMA3C's biological roles, our knockout cell lines offer exceptional value. They empower users to make significant discoveries that could translate into clinical applications, ultimately advancing the field of molecular biology and translational medicine. Our company prides itself on delivering high-quality, innovative biological products backed by extensive expertise in gene editing techniques, ensuring that our customers have access to the best resources for their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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