Gene: SELENOP
Official Full Name: selenoprotein Pprovided by HGNC
Gene Summary: This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35477 | SELENOP Knockout cell line (HeLa) | Human | SELENOP | 1:3~1:6 | Negative | Online Inquiry |
KO35478 | SELENOP Knockout cell line (HCT 116) | Human | SELENOP | 1:2~1:4 | Negative | Online Inquiry |
KO35479 | SELENOP Knockout cell line (HEK293) | Human | SELENOP | 1:3~1:6 | Negative | Online Inquiry |
SELENOP Gene Knockout Cell Lines represent an exceptional innovation in the realm of genetic research, specifically designed to facilitate the study of selenoprotein functions in cellular biology. These cell lines are engineered using advanced CRISPR-Cas9 technology to achieve precise knockout of the SELENOP gene, which encodes the selenoprotein known as selenoprotein P. This alteration enables researchers to investigate the biochemical pathways and physiological impacts associated with reduced selenium transport and its implications on health and disease.
The key function of SELENOP Gene Knockout Cell Lines lies in their ability to simulate conditions reflective of selenium deficiency in a controlled environment. The mechanism involves the disruption of the SELENOP gene, leading to a significant decrease in selenoprotein synthesis. Researchers can utilize these cell lines to understand how Selenium affects oxidative stress response, immune function, and neurodegenerative diseases, as SELENOP is critical for selenium homeostasis and antioxidant defense.
The scientific importance of these cell lines extends into both research and clinical applications. They enable investigators to explore the role of selenium in cancer biology, cardiovascular disease, and metabolic disorders, thereby contributing valuable insights into potential therapeutic targets and nutritional interventions. Furthermore, these cell lines are invaluable tools for pharmacological studies that assess the efficacy of selenium-based compounds.
Compared to alternate models, SELENOP Gene Knockout Cell Lines offer unparalleled specificity and reliability. Other models may lack the precise genetic alterations required to mimic physiological conditions accurately, whereas these knockout lines provide a clear and focused platform to study SELENOP-related pathways without confounding effects.
For researchers and clinicians, the value of SELENOP Gene Knockout Cell Lines lies in their capacity to enhance understanding of selenium’s multifaceted role in health, ultimately paving the way for improved therapeutic strategies and dietary recommendations. Additionally, our company boasts a rich history of innovation in genetic research tools, ensuring that our products are backed by solid scientific principles and rigorous quality standards. This commitment supports our mission to aid the advancement of biomedical research and improve clinical outcomes worldwide.
Please note that all services are for research use only. Not intended for any clinical use.
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