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SELENOO Knockout Cell Lines

Gene: SELENOO

Official Full Name: selenoprotein Oprovided by HGNC

Gene Summary: This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00935 SELENOO Knockout cell line(HeLa) Human SELENOO 1:3~1:6 Negative Online Inquiry
KO14232 SELENOO Knockout cell line (HCT 116) Human SELENOO 1:2~1:4 Negative Online Inquiry
KO14233 SELENOO Knockout cell line (HEK293) Human SELENOO 1:3~1:6 Negative Online Inquiry
KO14234 SELENOO Knockout cell line (A549) Human SELENOO 1:3~1:4 Negative Online Inquiry

Background

SELENOO Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study of gene function and regulation by creating targeted deletions or disruptions in the SELENOO gene. This innovative product serves as a vital tool for researchers seeking to explore the physiological roles of the SELENOO gene, which is implicated in various biological processes, including selenoprotein synthesis and cellular response to oxidative stress.

The key function of SELENOO Gene Knockout Cell Lines lies in their ability to elucidate the specific contributions of SELENOO in cellular pathways. By employing CRISPR-Cas9 technology, these cell lines precisely modify the genome, allowing researchers to observe the downstream effects of gene knockout on cell behavior, phenotype, and signaling cascades. This mechanistic insight is essential for advancing our understanding of both basic biology and the pathophysiology of diseases associated with selenium metabolism.

In terms of scientific significance, SELENOO Gene Knockout Cell Lines hold immense potential for applications in both research and clinical contexts. In the laboratory, they are invaluable for drug discovery processes, fostering insights into therapeutic targets for conditions linked to altered selenoprotein functions. Clinically, they contribute to the identification of biomarkers and novel treatment strategies for diseases such as cancer and neurodegenerative disorders, where selenium has shown promise.

Compared to alternative models, SELENOO Gene Knockout Cell Lines offer enhanced precision and reliability. They provide a consistent, reproducible platform for experiments, reducing variability often seen in primary cell cultures or non-targeted knockouts. Furthermore, the specific knockout of the SELENOO gene allows for focused investigations into its unique roles, making these models superior for research purposes.

By utilizing SELENOO Gene Knockout Cell Lines, researchers and clinicians gain a powerful resource that accelerates the discovery of new biological insights and therapeutic avenues. The ability to dissect gene function with such clarity presents a compelling advantage for advancing scientific knowledge.

Developed by a team of experts in genetic engineering and cell biology, our company is committed to offering high-quality, rigorously validated biological products that facilitate groundbreaking research. Our SELENOO Gene Knockout Cell Lines exemplify this commitment, providing the tools necessary to unlock new discoveries in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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