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SELENOF Knockout Cell Lines

Gene: SELENOF

Official Full Name: selenoprotein Fprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33262 SELENOF Knockout cell line (HeLa) Human SELENOF 1:3~1:6 Negative Online Inquiry
KO33263 SELENOF Knockout cell line (HCT 116) Human SELENOF 1:2~1:4 Negative Online Inquiry
KO33264 SELENOF Knockout cell line (HEK293) Human SELENOF 1:3~1:6 Negative Online Inquiry
KO33265 SELENOF Knockout cell line (A549) Human SELENOF 1:3~1:4 Negative Online Inquiry

Background

SELENOF Gene Knockout Cell Lines are advanced model systems specifically engineered to lack the SELENOF gene, which encodes for selenoprotein F—a crucial protein involved in redox homeostasis and cellular stress responses. These knockout cell lines serve as invaluable tools for investigating the multifaceted role of selenium and selenoproteins within cellular processes, particularly in the context of metabolism and oxidative stress. By removing the SELENOF gene, researchers can closely examine the gene's functional significance and the broader implications of selenoprotein activity in various biological contexts.

The key function of SELENOF Gene Knockout Cell Lines lies in their ability to provide a controlled environment for studying the mechanisms of cell survival, differentiation, and apoptosis in response to selenium levels. Additionally, they allow for the exploration of how the disruption of SELENOF impacts cellular redox balance and susceptibility to oxidative damage. This precise mechanism enables researchers to draw clearer conclusions about the physiological role of SELENOF in health and disease, including cancer and neurodegenerative disorders.

In research and clinical settings, these knockout cell lines are essential for elucidating the molecular pathways involved in selenoprotein research. They facilitate drug discovery by serving as platforms for screening potential therapeutic agents that target redox-related diseases. The scientific importance of SELENOF Gene Knockout Cell Lines is underscored by their ability to replicate aspects of human physiology, allowing for translatable insights that can inform clinical practices.

Compared to traditional cell lines, SELENOF knockout variants offer unique advantages such as enhanced specificity and sensitivity in research experiments. Their targeted genetic modification enables more reliable results, minimizing the confounding effects observed in wild-type cells. Furthermore, their adaptability to various experimental conditions positions them as superior models for studying selenoprotein biology.

For researchers, clinicians, and pharmaceutical companies, investing in SELENOF Gene Knockout Cell Lines translates to access to cutting-edge tools that can expedite the understanding of selenium's role in human health and disease. Our company is committed to providing high-quality biological products, backed by a team of experts dedicated to advancing scientific research through innovative solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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