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SEC24C Knockout Cell Lines

Gene: SEC24C

Official Full Name: SEC24 homolog C, COPII coat complex componentprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01017 SEC24C Knockout cell line (HEK293) Human SEC24C 1:3~1:6 Negative Online Inquiry
KO01407 SEC24C Knockout cell line(HeLa) Human SEC24C 1:3~1:6 Negative Online Inquiry
KO14247 SEC24C Knockout cell line (HCT 116) Human SEC24C 1:2~1:4 Negative Online Inquiry
KO14248 SEC24C Knockout cell line (A549) Human SEC24C 1:3~1:4 Negative Online Inquiry

Background

SEC24C Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the SEC24C gene, which is a crucial component of the COPII vesicular transport machinery responsible for the trafficking of proteins from the endoplasmic reticulum to the Golgi apparatus. By knocking out the SEC24C gene, these cell lines provide researchers with a powerful tool to study the mechanisms of protein secretion, cellular response to stress, and the overall impact of vesicular transport on cellular homeostasis.

The key function of SEC24C Gene Knockout Cell Lines lies in their ability to disrupt the normal protein transport pathways, enabling scientists to investigate how disrupted trafficking affects various biological processes. Researchers can utilize these cell lines to understand the implications of SEC24C loss on cellular signaling, protein misfolding, and various diseases associated with dysfunctional vesicular transport, such as cancer and neurological disorders.

The scientific importance of these cell lines cannot be overstated, as they facilitate groundbreaking research in both basic biology and clinical settings. They are invaluable for drug discovery, particularly in screening for pharmacological agents that may restore or enhance cellular transport processes. Furthermore, these knockout cell lines can be employed in functional studies to identify compensatory mechanisms that cells may engage in response to loss of SEC24C, thus providing insight into therapeutic targets.

Compared to traditional cell lines, SEC24C Gene Knockout Cell Lines offer a unique advantage: they create a more defined genetic background enabling clearer interpretation of results. While standard cell lines may exhibit variable responses due to multiple active pathways, the precise gene knockout allows researchers to achieve more reproducible and reliable experimental outcomes.

For researchers, clinicians, and drug developers seeking to elucidate the complexities of intracellular trafficking and develop targeted treatments, SEC24C Gene Knockout Cell Lines present an indispensable resource. They provide a platform for innovative discoveries that could lead to breakthroughs in understanding various pathologies related to protein mismanagement.

At our company, we pride ourselves on delivering high-quality, rigorously validated biological products that empower the scientific community. Our commitment to excellence and innovation ensures that our offerings, such as the SEC24C Gene Knockout Cell Lines, continuously meet the evolving needs of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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