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SEC24A Knockout Cell Lines

Gene: SEC24A

Official Full Name: SEC24 homolog A, COPII coat complex componentprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31500 SEC24A Knockout cell line (HeLa) Human SEC24A 1:3~1:6 Negative Online Inquiry
KO31501 SEC24A Knockout cell line (HCT 116) Human SEC24A 1:2~1:4 Negative Online Inquiry
KO31502 SEC24A Knockout cell line (HEK293) Human SEC24A 1:3~1:6 Negative Online Inquiry
KO31503 SEC24A Knockout cell line (A549) Human SEC24A 1:3~1:4 Negative Online Inquiry

Background

SEC24A Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology designed to investigate the roles of the SEC24A gene in various physiological and pathological processes. These cell lines have been genetically engineered to disrupt the SEC24A gene, a critical component of the COPII vesicle coating machinery responsible for the transport of proteins from the endoplasmic reticulum to the Golgi apparatus. By targeting this specific gene, researchers can gain insights into the mechanisms of intracellular trafficking, protein secretion, and cellular homeostasis.

Functional studies employing SEC24A knockout cell lines can elucidate the gene's contribution to cellular responses under stress conditions, such as inflammation and oncogenesis. This knockout model is instrumental in dissecting pathways that may modulate disease progression, therapeutic efficacy, and cellular behavior under various experimental paradigms. The ability to manipulate this gene allows for the development of innovative therapeutic strategies aimed at diseases where altered protein transport is a hallmark.

A significant advantage of using SEC24A Gene Knockout Cell Lines is their specificity and reliability, providing a precise tool for researchers looking to understand SEC24A's biological functions in detail. Unlike other genetic models that may display background activities or off-target effects, these knockout cell lines offer a clean genetic background that minimizes variability in experimental results.

For researchers and clinicians alike, the SEC24A knockout lines deliver considerable value in accelerating discoveries in fields such as cancer research and metabolic diseases, where understanding intracellular transport is crucial. As a leading provider of high-quality biological products, our company prides itself on its rigorous quality control and commitment to advancing the life sciences through innovative solutions tailored to meet the needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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