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SDCBP2 Knockout Cell Lines

Gene: SDCBP2

Official Full Name: syndecan binding protein 2provided by HGNC

Gene Summary: The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27827 SDCBP2 Knockout cell line (HCT 116) Human SDCBP2 1:2~1:4 Negative Online Inquiry
KO27828 SDCBP2 Knockout cell line (HEK293) Human SDCBP2 1:3~1:6 Negative Online Inquiry

Background

SDCBP2 Gene Knockout Cell Lines are genetically engineered cell lines designed to extinguish expression of the SDCBP2 gene, a critical player in cellular functions such as signal transduction, cytoskeletal organization, and endocytosis. This knockout technology relies on CRISPR/Cas9 genome-editing tools, which introduce targeted double-stranded breaks in the DNA, leading to frameshift mutations that effectively disrupt the gene's coding sequence. As a result, researchers can study the phenotypic consequences of SDCBP2 loss, providing insights into its role in cellular dynamics and disease pathology.

The SDCBP2 gene has been implicated in various biological processes, making these knockout cell lines of significant scientific value. Their applications span basic research, where they serve as a model to determine the gene's involvement in cancer progression and metastasis, to therapeutic development, where understanding SDCBP2 may inform novel treatment avenues. Additionally, in the context of regenerative medicine, these cell lines allow for the exploration of how SDCBP2 influences stem cell behavior and differentiation.

What sets SDCBP2 Gene Knockout Cell Lines apart from alternatives is their precise gene targeting, which minimizes off-target effects commonly associated with older gene-editing techniques. Our lines come well-characterized, offering robust and reproducible results, saving researchers valuable time during their experimental designs. Furthermore, each knockout is validated through comprehensive sequencing and functional assays, ensuring high-quality data integrity.

For researchers and clinicians eager to delve into the complexities of gene function and pathology, SDCBP2 Gene Knockout Cell Lines provide an unparalleled tool, enabling cutting-edge exploration into mechanisms of disease and potential therapeutic targets. As a leader in biotechnological innovations, our company is committed to equipping the scientific community with high-quality, reliable products tailored to advance research and enhance clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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