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SCEL Knockout Cell Lines

Gene: SCEL

Official Full Name: sciellinprovided by HGNC

Gene Summary: The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33868 SCEL Knockout cell line (A549) Human SCEL 1:3~1:4 Negative Online Inquiry

Background

SCEL Gene Knockout Cell Lines are specialized cellular models developed to study the functional role of the SCEL gene, critical in epithelial tissue and skin homeostasis. These cell lines are engineered using advanced CRISPR-Cas9 gene editing technologies that ensure precise elimination of the SCEL gene, allowing researchers to observe the resulting phenotypic changes and molecular pathways influenced by its absence.

The key mechanism by which SCEL gene knockout cell lines operate involves targeted modification of the genomic sequence, leading to frameshift mutations that disrupt the production of the encoded protein. This provides an invaluable tool for dissecting the biology of keratinocyte differentiation and assessing the impact of SCEL on cellular adhesion and structural integrity in epithelium.

In terms of scientific importance, these cell lines serve as crucial resources in both research and clinical applications. They are particularly useful in dermatological studies, cancer research, and regenerative medicine, facilitating the understanding of skin disorders, wound healing, and cancer pathogenesis associated with epithelial cells. Moreover, these cell lines can aid in high-throughput screening for novel therapeutic compounds that target SCEL-related pathways.

One of the specific advantages of SCEL Gene Knockout Cell Lines is their reliability and reproducibility in experimental outcomes. Unlike other genetic manipulation methods that may yield off-target effects or variable results, our CRISPR-Cas9 engineered lines offer consistent and efficient knockout capability, ensuring the validity of research findings. Additionally, the user-friendly protocols and comprehensive supporting data provided with the product enhance ease of integration into existing workflows.

For researchers and clinicians aiming to advance their understanding of epithelial biology and associated disorders, the SCEL Gene Knockout Cell Lines are an invaluable asset. They not only provide insights into gene function but also present opportunities for the development of targeted therapies.

At our company, we pride ourselves on our commitment to excellence in providing high-quality biological tools, driven by expert knowledge and cutting-edge technology. Our focus on innovation ensures that we support the scientific community with top-tier products like the SCEL Gene Knockout Cell Lines, fostering advancements in research that propel both understanding and application in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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