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SCARB1 Knockout Cell Lines

Gene: SCARB1

Official Full Name: scavenger receptor class B member 1provided by HGNC

Gene Summary: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05837 SCARB1 Knockout cell line (HeLa) Human SCARB1 1:3~1:6 Negative Online Inquiry
KO05838 SCARB1 Knockout cell line (HCT 116) Human SCARB1 1:2~1:4 Negative Online Inquiry
KO05839 SCARB1 Knockout cell line (HEK293) Human SCARB1 1:3~1:6 Negative Online Inquiry
KO05840 SCARB1 Knockout cell line (A549) Human SCARB1 1:3~1:4 Negative Online Inquiry

Background

SCARB1 Gene Knockout Cell Lines represent a breakthrough resource in genetic research and therapeutic development, specifically designed to target and eliminate the SCARB1 gene's expression in cultured cells. This gene plays a crucial role in the endocytosis of lipoproteins and the metabolism of cholesterol, making it vital for understanding cardiovascular diseases and metabolic disorders. By utilizing CRISPR/Cas9 technology, these cell lines provide an efficient and reliable model for studying the biological consequences of SCARB1 gene deletion, facilitating the exploration of its role in lipid metabolism and associated pathologies.

The SCARB1 knockout cell lines function by utilizing precise genomic editing to disrupt the SCARB1 gene, enabling researchers to investigate the resulting phenotypic changes in cellular behavior, signaling pathways, and metabolic responses. This gene deletion model mimics pathological conditions, ultimately aiding in the identification of novel therapeutic targets and drug screening for heart disease and metabolic syndromes.

From a scientific perspective, the SCARB1 Gene Knockout Cell Lines have significant applications in both basic research and clinical settings. They are invaluable for elucidating the molecular mechanisms underlying atherogenesis, studying cellular responses to lipid stress, and assessing the impact of SCARB1 on the pathophysiology of diseases such as atherosclerosis and diabetes. Researchers can also use these models to evaluate the efficacy of new pharmacological agents aimed at modulating lipid metabolism.

What sets the SCARB1 Gene Knockout Cell Lines apart from similar products is their high specificity and the quality assurance of rigorous validation processes, ensuring reproducibility of results. Unlike other genetically modified cell lines, these knockout models offer unparalleled reliability in studying gene function without the confounding factors associated with partial knockdowns or uncharacterized mutations.

In addition to enhancing the depth and credibility of research findings, using SCARB1 Gene Knockout Cell Lines allows researchers and clinicians to advance their understanding of complex diseases grounded in lipid metabolism. Their ability to generate consistent and robust data makes them a valuable asset for academic laboratories and biotechnology firms alike.

With a proven track record in developing innovative biological products, our company stands ready to support your research needs through reliable, high-quality genetic tools such as our SCARB1 Gene Knockout Cell Lines, designed to empower the scientific community in their quest for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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