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SAV1 Knockout Cell Lines

Gene: SAV1

Official Full Name: salvador family WW domain containing protein 1provided by HGNC

Gene Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08599 SAV1 Knockout cell line (HeLa) Human SAV1 1:3~1:6 Negative Online Inquiry
KO08600 SAV1 Knockout cell line (HCT 116) Human SAV1 1:2~1:4 Negative Online Inquiry
KO08601 SAV1 Knockout cell line (HEK293) Human SAV1 1:3~1:6 Negative Online Inquiry
KO08602 SAV1 Knockout cell line (A549) Human SAV1 1:3~1:4 Negative Online Inquiry

Background

SAV1 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, designed to facilitate the investigation of the roles of the SAV1 gene in various cellular processes. These cell lines are engineered using CRISPR-Cas9 technology, leading to precise and efficient gene disruption, which allows for the detailed study of SAV1's function in cellular signaling pathways, tumorigenesis, and other essential biological roles.

The key function of these knockout cell lines lies in their ability to eliminate the expression of the SAV1 gene, providing a clear contrast to wild-type cells. This gene knockout enables researchers to elucidate the consequences of SAV1 loss on cell proliferation, apoptosis, and the response to stressors, thereby enhancing our understanding of its involvement in various diseases, particularly in cancer research. By providing a robust model, these cell lines allow for high-throughput screening of drug responses and gene interactions, enriching the dataset available for targeted therapies.

Scientifically, the importance of SAV1 Gene Knockout Cell Lines cannot be understated, as they serve as a vital resource for both basic research and translational applications. They are indispensable in deciphering the molecular mechanisms underlying cancer development and for the identification of potential therapeutic targets. This innovative product is particularly advantageous compared to alternatives such as traditional siRNA-mediated knockdown, as it offers permanent and stable gene disruption, minimizing the risk of off-target effects and providing consistent results in longitudinal studies.

For researchers and clinicians, the ability to manipulate and study the SAV1 gene in a controlled cellular environment is invaluable, paving the way for novel insights in disease mechanisms and therapeutics. Moreover, our company brings a wealth of expertise in genetic engineering and cell biology, ensuring that our SAV1 Gene Knockout Cell Lines meet the highest standards of quality and functionality. By choosing our product, users gain access to cutting-edge technology designed to advance their research initiatives effectively and efficiently.

Please note that all services are for research use only. Not intended for any clinical use.

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