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SAR1A Knockout Cell Lines

Gene: SAR1A

Official Full Name: secretion associated Ras related GTPase 1Aprovided by HGNC

Gene Summary: Enables G protein activity and amino acid sensor activity. Involved in COPII-coated vesicle budding; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Is active in COPII vesicle coat; endoplasmic reticulum exit site; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03899 SAR1A Knockout cell line (HeLa) Human SAR1A 1:3~1:6 Negative Online Inquiry
KO03900 SAR1A Knockout cell line (HCT 116) Human SAR1A 1:2~1:4 Negative Online Inquiry
KO03901 SAR1A Knockout cell line (HEK293) Human SAR1A 1:3~1:6 Negative Online Inquiry
KO03902 SAR1A Knockout cell line (A549) Human SAR1A 1:3~1:4 Negative Online Inquiry

Background

SAR1A Gene Knockout Cell Lines are genetically modified cellular systems designed to lack the SAR1A gene, which plays a crucial role in intracellular membrane trafficking and the regulation of vesicle budding processes. This product is invaluable for researchers investigating the molecular mechanisms of endocytosis, exocytosis, and overall cellular transport dynamics. The knockout of the SAR1A gene effectively elucidates its role in pathogenic processes and cellular functionalities, providing a clear context for studying various cellular responses and disease pathways.

These cell lines function by creating a precise genetic alteration that enables researchers to observe the direct consequences of SAR1A depletion. By utilizing CRISPR-Cas9 technology, the knockout process yields high efficiency and specificity, allowing for seamless applications in functional assays and pathway analyses. This mechanistic insight is critical not only for basic biological research but also for advancing understanding of diseases, such as cancer and neurodegenerative disorders, where improper protein trafficking can lead to pathophysiological outcomes.

The scientific importance of SAR1A Gene Knockout Cell Lines extends to their application in drug discovery and development, where they can serve as useful tools to identify and validate potential therapeutic targets. Compared to traditional cell lines, these knockout versions offer a more refined approach, delivering enhanced specificity in experimental results that can significantly improve the quality of data obtained.

What sets SAR1A Gene Knockout Cell Lines apart from other alternatives is their robust pedigree, characterized by meticulous validation and functional assays that demonstrate the reliability of the knockout. Researchers can be confident that this product will yield reproducible and relevant results, ultimately speeding up the pace of discovery and innovative research.

For researchers and clinicians aiming to push the boundaries of cellular biology, the SAR1A Gene Knockout Cell Lines represent an essential asset in elucidating molecular pathways and developing novel therapeutic interventions. Our company prides itself on a commitment to delivering high-quality, scientifically validated products, supported by extensive expertise in genetic engineering and cellular models, ensuring that our customers are equipped with the tools necessary for transformative research.

Please note that all services are for research use only. Not intended for any clinical use.

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