Gene: SAFB
Official Full Name: scaffold attachment factor Bprovided by HGNC
Gene Summary: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35534 | SAFB Knockout cell line (HeLa) | Human | SAFB | 1:3~1:6 | Negative | Online Inquiry |
KO35535 | SAFB Knockout cell line (HCT 116) | Human | SAFB | 1:2~1:4 | Negative | Online Inquiry |
KO35536 | SAFB Knockout cell line (HEK293) | Human | SAFB | 1:3~1:6 | Negative | Online Inquiry |
KO35537 | SAFB Knockout cell line (A549) | Human | SAFB | 1:3~1:4 | Negative | Online Inquiry |
SAFB Gene Knockout Cell Lines are genetically engineered cell models designed to specifically eliminate the expression of the SAFB gene, which encodes for the scaffold attachment factor B. These cell lines serve as invaluable tools for researchers investigating the role of SAFB in diverse cellular processes, including transcription regulation, RNA processing, and chromatin remodeling. By creating targeted knockouts, scientists can elucidate the functional consequences of SAFB deficiency, thereby advancing our understanding of gene expression regulation and its implications in various diseases, such as cancer and neurodegeneration.
The primary mechanism of SAFB Gene Knockout Cell Lines involves the use of CRISPR-Cas9 technology, a revolutionary genome-editing tool that allows for precise modifications of the genomic DNA. This system effectively disrupts the coding sequence of the SAFB gene, leading to a loss of protein expression. As a result, researchers can study the downstream effects of SAFB depletion, enabling them to identify critical pathways influenced by this factor.
The significance of SAFB Gene Knockout Cell Lines extends to both basic research and potential clinical applications. In a research context, these cell lines facilitate the investigation of SAFB's role in pathological conditions and can serve as a model for screening novel therapeutic agents targeting related pathways. Furthermore, in clinical settings, the insights gained from studies utilizing these knockouts may pave the way for innovative strategies to manipulate gene expression in therapeutic contexts.
Compared to alternative gene knockout models, SAFB Gene Knockout Cell Lines offer a high degree of specificity and efficiency, minimizing off-target effects often associated with traditional gene-editing methods. The reproducibility and reliability of these cell lines provide researchers with confidence in their experimental results, making them an essential resource for both academic and industry researchers alike.
For those invested in advancing their research, SAFB Gene Knockout Cell Lines are not only valuable assets but also a gateway to uncovering new therapeutic strategies. With years of expertise in the field of molecular biology and a commitment to delivering high-quality biological products, our company is dedicated to supporting the scientific community with innovative solutions tailored to meet the needs of researchers and clinicians.
Please note that all services are for research use only. Not intended for any clinical use.
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