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S100P Knockout Cell Lines

Gene: S100P

Official Full Name: S100 calcium binding protein Pprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35531 S100P Knockout cell line (HeLa) Human S100P 1:3~1:6 Negative Online Inquiry
KO35532 S100P Knockout cell line (HCT 116) Human S100P 1:2~1:4 Negative Online Inquiry
KO35533 S100P Knockout cell line (A549) Human S100P 1:3~1:4 Negative Online Inquiry

Background

S100P Gene Knockout Cell Lines are genetically engineered cell lines that have had the S100P gene functionally disrupted, or "knocked out," allowing for the study of the gene’s role in various biological processes and diseases. The S100P gene encodes a member of the S100 family of proteins, which are involved in regulating multiple cellular activities, including cell growth, differentiation, motility, and apoptosis. By utilizing gene knockout techniques such as CRISPR-Cas9 technology, these cell lines provide researchers with a powerful tool to explore the functional implications of S100P absence in both normal and pathological contexts.

The primary function of S100P involves its participation in calcium-binding and signaling pathways, influencing cellular responses to various stimuli. In cancer research, for example, S100P has been implicated in tumor progression, metastasis, and response to chemotherapy. The knockout cell lines allow researchers to observe changes in cellular behavior and signaling cascades in the absence of S100P, providing critical insights into its physiological and pathological roles.

The scientific importance of S100P Gene Knockout Cell Lines extends to both fundamental research and translational applications. These cell lines can be utilized to investigate cancer biology, neurodegenerative diseases, and other conditions where S100P is believed to play a crucial role. They serve as invaluable models for testing new therapeutic approaches and can facilitate the development of targeted treatments.

Compared to traditional wild-type cell lines, S100P knockout cell lines offer distinct advantages, including the elimination of confounding factors associated with gene expression variability. This specificity enhances the reliability of experimental results and supports the generation of more precise data. Furthermore, these knockout models allow researchers to design controlled experiments that elucidate the mechanisms of action of S100P, leading to a deeper understanding of its biological significance.

For researchers and clinicians, the S100P Gene Knockout Cell Lines represent an essential resource for exploring this critical gene’s role in health and disease. The ability to manipulate and study S100P in specific contexts offers the potential for groundbreaking discoveries and advancements in therapeutic strategies.

With a proven track record in the development of specialized cell lines and a commitment to quality and innovation, our company stands ready to support researchers in their quest for knowledge and discovery. Our expertise in genetic engineering underpins the reliability and effectiveness of the S100P Gene Knockout Cell Lines, empowering scientists in their important work.

Please note that all services are for research use only. Not intended for any clinical use.

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