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S100A1 Knockout Cell Lines

Gene: S100A1

Official Full Name: S100 calcium binding protein A1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35549 S100A1 Knockout cell line (HeLa) Human S100A1 1:3~1:6 Negative Online Inquiry
KO35550 S100A1 Knockout cell line (HCT 116) Human S100A1 1:2~1:4 Negative Online Inquiry
KO35551 S100A1 Knockout cell line (HEK293) Human S100A1 1:3~1:6 Negative Online Inquiry
KO35552 S100A1 Knockout cell line (A549) Human S100A1 1:3~1:4 Negative Online Inquiry

Background

S100A1 Gene Knockout Cell Lines represent a sophisticated tool for researchers engaged in the exploration of cellular signaling and pathology associated with the S100 protein family. These cell lines are genetically engineered to specifically disrupt the S100A1 gene, which encodes a protein that plays a critical role in calcium signaling, cellular growth, and differentiation, particularly within cardiac and skeletal muscle tissues.

The primary function of S100A1 in these systems includes modulation of intracellular calcium levels, influencing contractile function and cellular responses to external stimuli. By knocking out this gene, researchers can elucidate the specific roles of S100A1 in various physiological processes and pathologies, including heart failure, diabetes, and certain malignancies. The mechanistic insights gained from these cell lines could lead to breakthroughs in understanding S100 family proteins and their involvement in disease states.

The scientific significance of S100A1 Gene Knockout Cell Lines is profound, allowing for the in-depth study of gene function in vitro, alongside providing a model system to evaluate the effects of pharmacological agents. In clinical settings, such models can facilitate the identification of potential therapeutic targets and the testing of novel drug compounds aimed at modulating S100A1 activity.

A key advantage of our S100A1 Gene Knockout Cell Lines is their robust characterization and validation, ensuring high reproducibility in experimental outcomes. These cell lines are derived from well-established backgrounds, improving translatability to relevant physiological contexts compared to other generic knockout models. Additionally, our proprietary technology enhances the precision of the gene editing process, minimizing off-target effects that often plague alternative products.

For researchers and clinicians alike, the S100A1 Gene Knockout Cell Lines provide a compelling opportunity to unlock new pathways in biomedical research while fostering innovation in therapeutic approaches. This product represents not just a scientific reagent but a catalyst for discovery in cellular biology.

At our company, we pride ourselves on our extensive experience in the production of genetically engineered cellular models, complemented by a commitment to quality and customer support that empowers researchers in their quest for scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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