Gene: RYR3
Official Full Name: ryanodine receptor 3provided by HGNC
Gene Summary: The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08450 | RYR3 Knockout cell line (HeLa) | Human | RYR3 | 1:3~1:6 | Negative | Online Inquiry |
RYR3 Gene Knockout Cell Lines are sophisticated biological research tools designed to facilitate the study of the ryanodine receptor 3 (RYR3) gene and its associated signaling pathways. These cell lines are engineered through targeted gene knockout techniques, which specifically create a genetic mutation that inactivates the RYR3 gene. This inactivation provides a vital resource for researchers aiming to evaluate the physiological and pathological roles of RYR3, particularly in muscle function, calcium signaling, and related cardiovascular conditions.
The key mechanism behind these cell lines involves the disruption of RYR3 expression, which significantly affects cellular calcium homeostasis and contractility. By eliminating the receptor’s function, researchers can observe downstream effects that cascade through various biological processes, ranging from muscle contraction to neuronal excitability. This allows for a comprehensive understanding of the gene’s contribution to both normal physiology and disease states, making it invaluable in exploring therapeutic interventions.
The scientific importance of RYR3 Gene Knockout Cell Lines extends into various applications such as drug discovery, functional genomics, and disease modeling. They can serve as robust models for cardiac and muscle disorders, ultimately aiding in the development of targeted therapies.
What sets our RYR3 Gene Knockout Cell Lines apart from competing products is our commitment to precision engineering and validation. Each cell line is rigorously characterized to ensure mutation integrity and functional disruption, paired with comprehensive documentation to aid reproducibility in experiments. These features not only enhance the reliability of the findings but also provide a streamlined integration into existing research frameworks.
For researchers and clinicians, these cell lines represent a powerful asset for elucidating the complexities of calcium signaling pathways, translating to better diagnostic and therapeutic strategies. The clarity and reliability of our products empower users in their quest for scientific discovery, reinforcing their experimental outcomes.
With years of expertise in the development of innovative biological products, our company remains at the forefront of facilitating advanced research tools that drive excellence in scientific inquiry. Our dedication is reflected in the high quality of our RYR3 Gene Knockout Cell Lines, providing you with the best resources for groundbreaking research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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