Gene: RUFY3
Official Full Name: RUN and FYVE domain containing 3provided by HGNC
Gene Summary: This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30169 | RUFY3 Knockout cell line (HeLa) | Human | RUFY3 | 1:3~1:6 | Negative | Online Inquiry |
KO30170 | RUFY3 Knockout cell line (HCT 116) | Human | RUFY3 | 1:2~1:4 | Negative | Online Inquiry |
KO30171 | RUFY3 Knockout cell line (HEK293) | Human | RUFY3 | 1:3~1:6 | Negative | Online Inquiry |
KO30172 | RUFY3 Knockout cell line (A549) | Human | RUFY3 | 1:3~1:4 | Negative | Online Inquiry |
RUFY3 Gene Knockout Cell Lines are specialized cellular models engineered to lack the RUFY3 gene, a protein-coding gene implicated in various cellular processes, including vesicle trafficking and cytoskeletal organization. By using CRISPR-Cas9 gene-editing technology, these knockout lines allow researchers to directly investigate the functional consequences of RUFY3 deficiency within cellular environments, thereby elucidating its role in both normal physiology and disease states.
The key function of RUFY3 involves regulating intracellular signaling pathways that affect cell motility and response to external stimuli. By creating a knockout model, researchers can dissect the signaling cascades that are disrupted in its absence, providing insights into mechanisms of diseases such as cancer, neurodegeneration, and developmental disorders. This utility makes RUFY3 Gene Knockout Cell Lines invaluable in experimental settings, contributing significantly to our understanding of gene function and interactions.
In a comparative context, RUFY3 Gene Knockout Cell Lines offer distinct advantages over conventional models. They provide a targeted approach, reducing the variability often seen in chemically induced models. Furthermore, these cell lines can be used alongside genome-wide crispr screening applications, facilitating high-throughput analysis of cellular responses and drug screening efforts. This precision and efficiency are a game-changer for researchers looking to identify novel therapeutic targets or mechanisms of action.
Our RUFY3 Gene Knockout Cell Lines are particularly valuable to academic and pharmaceutical researchers, offering a robust platform for innovative investigations into gene function. With a commitment to scientific advancement and quality, our company specializes in providing cutting-edge biological products that empower researchers to explore the complexities of genetics, ultimately contributing to improved therapeutic strategies and understanding of human health.
Please note that all services are for research use only. Not intended for any clinical use.
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