Gene: RTKN2
Official Full Name: rhotekin 2provided by HGNC
Gene Summary: Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of non-canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28516 | RTKN2 Knockout cell line (HeLa) | Human | RTKN2 | 1:3~1:6 | Negative | Online Inquiry |
KO28517 | RTKN2 Knockout cell line (HCT 116) | Human | RTKN2 | 1:2~1:4 | Negative | Online Inquiry |
KO28518 | RTKN2 Knockout cell line (HEK293) | Human | RTKN2 | 1:3~1:6 | Negative | Online Inquiry |
KO28519 | RTKN2 Knockout cell line (A549) | Human | RTKN2 | 1:3~1:4 | Negative | Online Inquiry |
RTKN2 Gene Knockout Cell Lines are specialized cellular systems in which the RTKN2 gene, crucial for various cellular functions and signaling pathways, has been selectively disrupted. These cell lines enable researchers to investigate the biological roles of RTKN2 in a controlled environment, offering a powerful tool for unraveling the complexities of cellular signaling, proliferation, and apoptosis. The knockout mechanism is typically achieved through precise genome editing techniques such as CRISPR/Cas9, resulting in a loss-of-function model that allows for thorough examination of the gene’s contributions to cellular behavior.
The primary function of RTKN2 involves its role in modulating the Rho signaling pathway, impacting cytoskeletal dynamics and influencing cellular morphology and movement. Understanding the knockdown effects on cells can illuminate pathways related to cancer progression, neurodegenerative diseases, and other conditions where RTKN2 is implicated. These cell lines can be invaluable in assessing drug responses and elucidating potential therapeutic targets.
In research and clinical settings, RTKN2 Gene Knockout Cell Lines are essential for validating hypotheses regarding gene function, phenotypic changes, and therapeutic interventions. Their unique offering is the specificity of the RTKN2 target, making them an ideal choice for researchers focused on signaling pathways associated with malignancies and cell migration.
Compared to traditional methods, these knockout lines provide a clean genetic background devoid of confounding variables, allowing for reproducibility and higher confidence in observed outcomes. This specificity enhances the overall validity and reliability of research findings, making them exceptionally valuable to scientists and clinicians alike.
By leveraging our extensive experience in genetic engineering and cell line development, we ensure that our RTKN2 Gene Knockout Cell Lines are produced under stringent quality controls, providing researchers with the consistency and reliability necessary for groundbreaking scientific explorations and potential clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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