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RRAGA Knockout Cell Lines

Gene: RRAGA

Official Full Name: Ras related GTP binding Aprovided by HGNC

Gene Summary: Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and tumor necrosis factor-mediated signaling pathway. Located in GATOR1 complex; lysosome; and nucleoplasm. Part of FNIP-folliculin RagC/D GAP. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09217 RRAGA Knockout cell line (HeLa) Human RRAGA 1:3~1:6 Negative Online Inquiry
KO09218 RRAGA Knockout cell line (HCT 116) Human RRAGA 1:2~1:4 Negative Online Inquiry
KO09219 RRAGA Knockout cell line (HEK293) Human RRAGA 1:3~1:6 Negative Online Inquiry
KO09220 RRAGA Knockout cell line (A549) Human RRAGA 1:3~1:4 Negative Online Inquiry

Background

RRAGA Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the expression of the RRAGA gene, which encodes a critical component of the Rag GTPase complex involved in the regulation of mTOR signaling and nutrient sensing pathways. These knockout cell lines provide researchers with a powerful tool to investigate the role of RRAGA in cellular metabolism, growth regulation, and autophagy. By removing the functional RRAGA gene, these cell lines enable a clearer understanding of how metabolic pathways are influenced by the absence of this key player, paving the way for novel therapeutic strategies.

The primary function of RRAGA Gene Knockout Cell Lines lies in their ability to facilitate the study of mTOR signaling under various physiological conditions. Scientists can utilize these cell lines to assess changes in cell proliferation, apoptosis, and metabolic alterations associated with nutrient availability and growth factor stimulation. The absence of RRAGA allows for a more pronounced examination of alternative signaling cascades that may compensate for its loss, thus contributing to a comprehensive understanding of cellular homeostasis.

The scientific importance of RRAGA Gene Knockout Cell Lines is evident in both fundamental research and clinical applications. In cancer biology, for instance, understanding the pathways regulated by mTOR and RRAGA can reveal potential targets for chemotherapeutic interventions and personalized medicine approaches. Furthermore, these cell lines can be instrumental in studying metabolic disorders and neurodegeneration, representing a valuable asset for academia and the pharmaceutical industry alike.

Compared to alternative models for studying the RRAGA gene, our knockout cell lines offer the advantage of specificity and reliability. They eliminate the confounding effects associated with partial loss of function or variability seen in knockdown systems, providing cleaner, more reproducible experimental outcomes. This precision enhances the accuracy of data interpretation, facilitating a more robust analysis of the underlying biological mechanisms involved.

For researchers, clinicians, and biotech firms focused on unraveling complex cellular pathways, RRAGA Gene Knockout Cell Lines represent an invaluable asset. Their ease of use, reliability, and specific applications make them indispensable for advancing scientific knowledge and therapeutic innovations.

Our company is dedicated to excellence in providing high-quality biological products that support groundbreaking research across various fields. Leveraging state-of-the-art technology and expert scientific knowledge, we ensure that our offerings meet the rigorous standards required by modern research environments, empowering our customers to achieve their scientific goals efficiently and effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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