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RP2 Knockout Cell Lines

Gene: RP2

Official Full Name: RP2 activator of ARL3 GTPaseprovided by HGNC

Gene Summary: The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35585 RP2 Knockout cell line (HeLa) Human RP2 1:3~1:6 Negative Online Inquiry
KO35586 RP2 Knockout cell line (HCT 116) Human RP2 1:2~1:4 Negative Online Inquiry
KO35587 RP2 Knockout cell line (HEK293) Human RP2 1:3~1:6 Negative Online Inquiry
KO35588 RP2 Knockout cell line (A549) Human RP2 1:3~1:4 Negative Online Inquiry

Background

RP2 Gene Knockout Cell Lines are cutting-edge biological tools developed to study the function of the RP2 gene, which is crucial for the regulation of lipid metabolism and retina development. These cell lines are generated using advanced CRISPR-Cas9 gene editing technology, allowing for precise knockout of the RP2 gene. By creating a functional loss of this gene, researchers can better understand the underlying molecular mechanisms contributing to retinal diseases, particularly those associated with X-linked Retinitis Pigmentosa.

The key function of RP2 Gene Knockout Cell Lines lies in their ability to mimic the pathophysiological conditions observed in patients with RP2 mutations. The mechanism of action is rooted in the knockout of the RP2 gene, leading to aberrant protein expression and subsequent disturbances in intracellular lipid transport and homeostasis. This enables scientists to elucidate the exact role of RP2 in disease progression and to identify potential therapeutic targets.

In terms of scientific importance, these cell lines are invaluable in both basic research and translational studies. They offer insights into disease mechanisms, enabling the development of gene therapies and pharmaceutical interventions aimed at mitigating the effects of RP2-related diseases. Furthermore, RP2 Gene Knockout Cell Lines serve as a powerful model for high-throughput screening of compounds that may restore function or provide symptomatic relief.

What sets RP2 Gene Knockout Cell Lines apart from other available models is their high specificity and reproducibility. Unlike traditional knockout models that may involve random integration or potential off-target effects, our lines are engineered with precision, ensuring a reliable simulation of RP2 functionality. This reliability not only accelerates the research timeline but also enhances the validity of experimental results.

Researchers and clinicians alike will find RP2 Gene Knockout Cell Lines to be an indispensable resource in their efforts to advance understanding of retinal diseases and to explore novel therapeutic avenues. Our company is dedicated to delivering high-quality biological research products, fortified by a strong foundation in genetic engineering and extensive experience in supporting the scientific community. Choose our RP2 Gene Knockout Cell Lines to enrich your research with state-of-the-art biotechnological advancements, ensuring cutting-edge results in your investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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