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ROCK2 Knockout Cell Lines

Gene: ROCK2

Official Full Name: Rho associated coiled-coil containing protein kinase 2provided by HGNC

Gene Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11687 ROCK2 Knockout cell line (HeLa) Human ROCK2 1:3~1:6 Negative Online Inquiry
KO11688 ROCK2 Knockout cell line (HCT 116) Human ROCK2 1:2~1:4 Negative Online Inquiry
KO11689 ROCK2 Knockout cell line (HEK293) Human ROCK2 1:3~1:6 Negative Online Inquiry
KO11690 ROCK2 Knockout cell line (A549) Human ROCK2 1:3~1:4 Negative Online Inquiry

Background

ROCK2 Gene Knockout Cell Lines represent a meticulously engineered biological tool designed for the study of cellular signaling pathways and their associated physiological processes. ROCK2, or Rho-associated coiled-coil kinase 2, is a vital serine/threonine kinase involved in various cellular functions such as cytoskeletal dynamics, cell migration, and apoptosis regulation. By utilizing CRISPR/Cas9 technology, these cell lines have been generated to effectively eliminate the expression of the ROCK2 gene, allowing researchers to study the consequences of its absence on cell behavior and molecular interactions.

The primary function of the ROCK2 Gene Knockout Cell Lines lies in their capacity to facilitate investigations into the signaling mechanisms modulated by ROCK2, thus shedding light on pathophysiological conditions, including cancer metastasis, cardiovascular diseases, and neurological disorders. The knockout of ROCK2 enables scientists to explore alternative compensatory pathways activated in its absence, providing invaluable insights into cellular adaptation and resilience.

In research and clinical settings, the ROCK2 Gene Knockout Cell Lines serve as a critical asset for drug discovery and validation, allowing for high-throughput screening of ROCK2-targeting compounds. Their application extends to neurobiological studies, where understanding the role of ROCK2 in neuronal development and function can lead to potential therapeutic targets for neurological conditions.

What sets our ROCK2 Gene Knockout Cell Lines apart is their unparalleled reliability and reproducibility, achieved through rigorous validation processes and comprehensive characterization. Unlike alternative models that may present variability or limited applicability, our cell lines provide a consistent platform for experimentation, reducing the risk of extraneous variability in results.

For researchers and clinicians focused on unraveling the complexities of cellular signaling and disease mechanisms, the ROCK2 Gene Knockout Cell Lines serve as a powerful tool that catalyzes discovery and innovation. Our company prides itself on its commitment to providing high-quality biological products, backed by extensive expertise in genetic manipulation and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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