Gene: ROBO1
Official Full Name: roundabout guidance receptor 1provided by HGNC
Gene Summary: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04398 | ROBO1 Knockout cell line (HeLa) | Human | ROBO1 | 1:3~1:6 | Negative | Online Inquiry |
KO04399 | ROBO1 Knockout cell line (HEK293) | Human | ROBO1 | 1:3~1:6 | Negative | Online Inquiry |
KO04400 | ROBO1 Knockout cell line (A549) | Human | ROBO1 | 1:3~1:4 | Negative | Online Inquiry |
ROBO1 Gene Knockout Cell Lines are specialized tools designed to facilitate in-depth studies of the ROBO1 gene, which plays a critical role in neuronal development and axon guidance. These cell lines are engineered using advanced CRISPR-Cas9 technology, allowing for the precise deletion of the ROBO1 gene, thereby enabling researchers to investigate the gene's functions and associated pathways in a controlled environment.
The primary function of these knockout cell lines lies in their ability to mimic pathogenic conditions where the ROBO1 gene is disrupted. By removing this specific gene, researchers can study the resultant impacts on cell signaling, migration, and differentiation, which are essential for understanding various neurological disorders and developmental anomalies. This mechanism provides a unique opportunity to elucidate the genetic and molecular underpinnings of conditions such as autism, schizophrenia, and other neurodevelopmental disorders.
The scientific importance of ROBO1 Gene Knockout Cell Lines extends into both research and clinical applications. They serve as a vital experimental model for drug discovery, allowing scientists to assess therapeutic interventions that could potentially rectify or compensate for the loss of ROBO1 function. Furthermore, these cell lines can be utilized in gene therapy research, helping to explore novel strategies for correcting genetic defects at the cellular level.
One of the key advantages of our ROBO1 Gene Knockout Cell Lines over alternative models is their specificity and reliability. Created under stringent conditions, these cell lines provide consistent results that enhance reproducibility and validity in experiments. Additionally, they come with comprehensive support from our experienced technical team, enabling researchers to optimize their experimental designs and obtain meaningful insights effectively.
For researchers and clinicians who aim to push the boundaries of genetic and neurological research, the value of ROBO1 Gene Knockout Cell Lines cannot be overstated. They represent a crucial resource for advancing our understanding of gene function and the molecular mechanisms underlying complex diseases.
Our company is dedicated to providing high-quality biological products backed by extensive research and development expertise, ensuring that our offerings meet the evolving needs of the scientific community. Through our commitment to innovation and excellence, we strive to empower researchers worldwide.
Please note that all services are for research use only. Not intended for any clinical use.
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