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RNF34 Knockout Cell Lines

Gene: RNF34

Official Full Name: ring finger protein 34provided by HGNC

Gene Summary: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26151 RNF34 Knockout cell line (HeLa) Human RNF34 1:3~1:6 Negative Online Inquiry
KO26152 RNF34 Knockout cell line (HCT 116) Human RNF34 1:2~1:4 Negative Online Inquiry
KO26153 RNF34 Knockout cell line (HEK293) Human RNF34 1:3~1:6 Negative Online Inquiry
KO26154 RNF34 Knockout cell line (A549) Human RNF34 1:3~1:4 Negative Online Inquiry

Background

RNF34 Gene Knockout Cell Lines are sophisticated biological tools designed to study the functions of the RNF34 gene, known for its role in protein turnover and the regulation of cellular stress response mechanisms. These cell lines have been genetically modified to create a complete knockout of the RNF34 gene, allowing researchers to investigate the biological ramifications of RNF34 loss in various cellular contexts.

The primary mechanism through which the RNF34 Gene Knockout Cell Lines operate is by eliminating the protein product of the RNF34 gene, which is implicated in the ubiquitin-proteasome pathway. By understanding how the absence of RNF34 affects cellular processes such as apoptosis, cell cycle regulation, and response to stressors, researchers can gain insights into the gene's role in homeostasis and disease pathology. This is particularly relevant in studies focusing on cancer biology, neurodegeneration, and immune responses, making these cell lines invaluable for both basic and applied scientific research.

The significance of RNF34 Gene Knockout Cell Lines extends into clinical applications, where they can be utilized to screen for potential therapeutic agents that may compensate for the loss of RNF34 function. Unlike traditional models that may provide incomplete or non-specific insights, these knockout cell lines deliver a precise genetic background that ensures reproducibility and reliability in experimental outcomes.

What sets our RNF34 Gene Knockout Cell Lines apart from other standard models is the rigorous validation process we undertake, ensuring high-quality and consistency across batches. Researchers will find these cell lines particularly advantageous due to their ease of use, versatility in experimental setups, and the ability to generate data that accurately reflect the consequences of RNF34 gene disruption.

Our commitment to providing high-quality biological resources, backed by extensive expertise and a solid foundation in molecular biology, ensures that our RNF34 Gene Knockout Cell Lines not only meet but exceed the expectations of researchers and clinicians. By choosing our product, you invest in reliable science that propels your research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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