Gene: RNF187
Official Full Name: ring finger protein 187provided by HGNC
Gene Summary: Enables ubiquitin-protein transferase activity. Involved in positive regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22328 | RNF187 Knockout cell line (HeLa) | Human | RNF187 | 1:3~1:6 | Negative | Online Inquiry |
KO22329 | RNF187 Knockout cell line (HCT 116) | Human | RNF187 | 1:2~1:4 | Negative | Online Inquiry |
KO22330 | RNF187 Knockout cell line (HEK293) | Human | RNF187 | 1:3~1:6 | Negative | Online Inquiry |
KO22331 | RNF187 Knockout cell line (A549) | Human | RNF187 | 1:3~1:4 | Negative | Online Inquiry |
RNF187 Gene Knockout Cell Lines are specially engineered cellular models designed to study the function of the RNF187 gene, which plays a crucial role in cellular processes such as protein ubiquitination and signal transduction. These knockout cell lines are created through precise gene-editing technologies, typically CRISPR-Cas9, which introduce deletions or mutations that disrupt the normal RNF187 gene expression.
The primary function of the RNF187 gene is associated with its E3 ubiquitin ligase activity, which marks proteins for degradation and regulates various cellular pathways. By removing the functional RNF187 gene through knockout methodologies, researchers can gain insights into the downstream effects on signaling pathways, cellular growth, and apoptosis, making these cell lines invaluable for functional genomics studies.
Scientifically, RNF187 Gene Knockout Cell Lines have significant implications in both basic and applied research. They provide a robust platform for investigating the mechanisms of diseases, such as cancer and neurodegenerative disorders, where aberrations in protein degradation pathways are often implicated. Additionally, these lines can serve as powerful models for drug discovery, allowing for the exploration of therapeutic compounds targeting uncontrolled cell proliferation or protein misfolding.
What sets our RNF187 Gene Knockout Cell Lines apart from alternatives is their validated performance and extensive characterization, ensuring researchers receive reliable and reproducible results. They are generated under stringent quality-controlled conditions and come with comprehensive usage guidelines, thus streamlining experimental workflows.
For researchers, clinicians, and biotechnology firms, investing in RNF187 Gene Knockout Cell Lines represents a strategic advantage. These cell lines facilitate innovative discoveries with potential translational applications, contributing to the development of targeted therapies and advanced treatment strategies.
Our company boasts extensive experience in the development of genetically engineered cell lines, underscoring our commitment to quality and reliability in every product we offer. We are dedicated to supporting the scientific community with advanced tools that foster groundbreaking research and improve clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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