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RNF144B Knockout Cell Lines

Gene: RNF144B

Official Full Name: ring finger protein 144Bprovided by HGNC

Gene Summary: Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21092 RNF144B Knockout cell line (HCT 116) Human RNF144B 1:2~1:4 Negative Online Inquiry
KO21093 RNF144B Knockout cell line (HEK293) Human RNF144B 1:3~1:6 Negative Online Inquiry
KO21094 RNF144B Knockout cell line (A549) Human RNF144B 1:3~1:4 Negative Online Inquiry

Background

RNF144B Gene Knockout Cell Lines are genetically engineered cell cultures specifically designed to facilitate the study of the RNF144B gene's functions in various biological processes. By utilizing CRISPR-Cas9 gene editing technology, these cell lines have been created to ensure the complete absence of RNF144B protein, allowing researchers to explore the phenotypic effects of its loss, unraveling its role in cellular pathways related to growth, differentiation, and disease.

The key function of these cell lines lies in providing a controlled environment to investigate the consequences of RNF144B gene knockout in human cell systems. The absence of the RNF144B protein enables the assessment of its impact on ubiquitination processes, apoptosis, and oncogenic signaling pathways. This targeted approach permits detailed analysis of downstream effects, elucidating molecular mechanisms that could be critical for cancer research, neurobiology, or immune response studies.

The scientific importance of RNF144B Gene Knockout Cell Lines is evident in their applications in both research and clinical settings. Researchers can utilize these cell lines to develop novel therapeutic strategies or discover biomarkers for diseases where RNF144B is implicated. Moreover, these models contribute to a better understanding of how gene regulation and protein function influence cellular behavior, paving the way for ground-breaking studies in genetic disorders and cancer biology.

Compared to alternative tools such as RNA interference or pharmacological inhibitors, RNF144B Gene Knockout Cell Lines provide a more precise and permanent modification of the genetic material. This results in more consistent and reproducible data, enhancing the reliability of experimental outcomes. The knockout approach allows for the complete absence of the target gene, which is particularly advantageous for dissecting the gene’s role without the variability and off-target effects often seen with other methods.

For researchers and clinicians aiming to delve deeper into the functions of RNF144B, these cell lines offer a valuable and innovative resource. With our commitment to high-quality genetic tools and deep understanding of cellular mechanisms, our company provides an extensive portfolio of genetic models and cell lines designed to support cutting-edge research and accelerate scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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