Gene: RNF144A
Official Full Name: ring finger protein 144Aprovided by HGNC
Gene Summary: This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32766 | RNF144A Knockout cell line (HeLa) | Human | RNF144A | 1:3~1:6 | Negative | Online Inquiry |
KO32767 | RNF144A Knockout cell line (HCT 116) | Human | RNF144A | 1:2~1:4 | Negative | Online Inquiry |
KO32768 | RNF144A Knockout cell line (HEK293) | Human | RNF144A | 1:3~1:6 | Negative | Online Inquiry |
KO32769 | RNF144A Knockout cell line (A549) | Human | RNF144A | 1:3~1:4 | Negative | Online Inquiry |
RNF144A Gene Knockout Cell Lines are a sophisticated set of genetically modified cell lines that have been engineered to lack the RNF144A gene, which is pivotal in various cellular processes including protein ubiquitination and cellular signaling pathways. This targeted knockout facilitates in-depth research into the gene's functional roles, its impact on cellular homeostasis, and its involvement in diseases, particularly those related to neurodegeneration and cancer.
The unique mechanism of these cell lines lies in their ability to provide a controlled environment for studying the absence of RNF144A and its associated effects on protein degradation pathways. By utilizing CRISPR-Cas9 technology, our RNF144A knockout cell lines demonstrate remarkable precision in disrupting the gene, thereby aiding researchers in uncovering the downstream effects of this modification. As a result, these cell lines serve as invaluable tools for elucidating molecular pathways and developing potential therapeutic strategies.
Scientifically, RNF144A Gene Knockout Cell Lines hold significant importance in both basic and applied research settings. They enable in-depth investigation into molecular mechanisms underlying cellular responses and may facilitate the discovery of novel drug targets. In clinical research, these cell lines offer a platform to validate hypotheses and assess pharmacological interventions, thereby supporting the translation of laboratory findings into therapeutic applications.
Compared to conventional cell lines, our RNF144A gene knockout variants provide a unique selling point through their specificity and efficiency in gene disruption. This eliminates off-target effects often associated with older methodologies, allowing for more reliable data generation. Furthermore, the ease of use and reproducibility of these lines enhances their appeal, making them a superior choice for researchers aiming to derive consistent and meaningful results.
For researchers and clinicians focused on advancing our understanding of gene function and therapeutic innovation, the RNF144A Gene Knockout Cell Lines represent a prime asset in cutting-edge genomic studies. Backed by our team's expertise in biological product development and our commitment to delivering high-quality resources, we are proud to offer this exceptional product that aligns with the needs of modern scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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