Gene: RIN3
Official Full Name: Ras and Rab interactor 3provided by HGNC
Gene Summary: Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09317 | RIN3 Knockout cell line (HeLa) | Human | RIN3 | 1:3~1:6 | Negative | Online Inquiry |
KO09318 | RIN3 Knockout cell line (HCT 116) | Human | RIN3 | 1:2~1:4 | Negative | Online Inquiry |
KO09319 | RIN3 Knockout cell line (HEK293) | Human | RIN3 | 1:3~1:6 | Negative | Online Inquiry |
KO09320 | RIN3 Knockout cell line (A549) | Human | RIN3 | 1:3~1:4 | Negative | Online Inquiry |
RIN3 Gene Knockout Cell Lines are specifically engineered cell lines that harbor a complete loss of function of the RIN3 gene, pivotal in regulating autophagy and cellular protein homeostasis. These cell lines have been developed using state-of-the-art CRISPR/Cas9 technology, enabling precise gene editing to facilitate the study of RIN3-related pathways in various biological contexts.
The key mechanism of RIN3 Gene Knockout Cell Lines involves the disruption of the RIN3 gene, which is implicated in multiple cellular processes, including endosomal trafficking and protein degradation. By providing a genetic framework wherein RIN3 is non-functional, researchers can explore the downstream effects on autophagic processes, evaluate the impact on neurodegenerative diseases, and study potential therapeutic approaches for conditions linked to protein aggregation.
In terms of scientific importance, these cell lines serve as vital tools in biomedical research and drug discovery, particularly in understanding the pathophysiology of diseases like Alzheimer's and Parkinson's. By allowing for detailed examination of RIN3's role in cellular metabolism and its implications in disease progression, these cell lines contribute significantly to the development of targeted therapies.
The unique selling points of RIN3 Gene Knockout Cell Lines include their robust validation, reproducibility, and user-friendly nature, making them ideal for both academic and commercial research settings. Unlike traditional cell models that may exhibit variable expression levels or functional activity, these knockout lines offer consistency and reliability, enabling researchers to draw more accurate conclusions from their experiments.
For researchers and clinicians, the value of RIN3 Gene Knockout Cell Lines lies in their potential to illuminate complex biological mechanisms and accelerate the identification of novel therapeutic targets. With a comprehensive understanding of RIN3's role, users can design experiments with improved outcomes and contribute to advancements in treatment strategies.
As an established provider of high-quality biological products, our company is dedicated to facilitating groundbreaking research through innovative solutions like the RIN3 Gene Knockout Cell Lines, embodying our commitment to advancing science and improving human health.
Please note that all services are for research use only. Not intended for any clinical use.
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