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RHOBTB1 Knockout Cell Lines

Gene: RHOBTB1

Official Full Name: Rho related BTB domain containing 1provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32579 RHOBTB1 Knockout cell line (HeLa) Human RHOBTB1 1:3~1:6 Negative Online Inquiry
KO32580 RHOBTB1 Knockout cell line (HCT 116) Human RHOBTB1 1:2~1:4 Negative Online Inquiry
KO32581 RHOBTB1 Knockout cell line (HEK293) Human RHOBTB1 1:3~1:6 Negative Online Inquiry
KO32582 RHOBTB1 Knockout cell line (A549) Human RHOBTB1 1:3~1:4 Negative Online Inquiry

Background

RHOBTB1 Gene Knockout Cell Lines are specialized cellular models designed for the in-depth study of the RHOBTB1 gene, which plays a pivotal role in diverse biological processes, including cellular proliferation, differentiation, and tumorigenesis. These knockout cell lines have been engineered to lack functional RHOBTB1 protein, allowing researchers to dissect the gene's specific contributions in various physiological contexts and disease states.

The primary function of RHOBTB1 involves its role as a member of the Rho family of GTPases, which are critical regulators of the actin cytoskeleton and cellular signaling pathways. By utilizing these knockout cell lines, scientists can investigate the downstream effects on signaling cascades such as the MAPK pathway, revealing how the absence of RHOBTB1 alters cellular behavior. This mechanistic insight is essential for elucidating the gene's involvement in conditions like cancer, neurodegenerative diseases, and other disorders where cytoskeletal dynamics are affected.

The scientific importance of RHOBTB1 Gene Knockout Cell Lines is underscored by their applications in both basic and translational research. They serve as vital tools for gene function studies, drug efficacy assessments, and potential therapeutic developments. Researchers can utilize these models for high-throughput screenings, target validation, and understanding gene interactions within cellular networks, thus positioning RHOBTB1 as a promising target for novel treatments.

What sets these knockout cell lines apart from conventional cell models is their stringent validation and specificity for the RHOBTB1 gene, ensuring that findings are directly attributable to the targeted gene disruption. Additionally, our cell lines are derived from widely used backgrounds, allowing for easier integration into existing research frameworks and enabling cross-study comparisons.

For researchers and clinicians aiming to explore the functional ramifications of RHOBTB1 and its therapeutic potential, our RHOBTB1 Gene Knockout Cell Lines provide an unparalleled advantage in study design and outcome reliability. With our extensive background in developing cutting-edge biological products, we are committed to supporting scientific discovery through innovative, high-quality offerings designed to meet the evolving needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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