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RHBG Knockout Cell Lines

Gene: RHBG

Official Full Name: Rh family B glycoproteinprovided by HGNC

Gene Summary: This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01700 RHBG Knockout cell line (HCT 116) Human RHBG 1:2~1:4 Negative Online Inquiry

Background

RHBG Gene Knockout Cell Lines are specific cell line models engineered to have a targeted deletion of the RHBG gene, which encodes a member of the SLC family of transporters known to be involved in physiological functions such as ammonia transport and acid-base balance. These knockout cell lines serve as invaluable tools for researchers in elucidating the precise role of the RHBG gene in cellular processes and disease mechanisms.

The primary function of RHBG Gene Knockout Cell Lines is to facilitate the study of gene function by removing the associated gene's expression. This allows scientists to discern the phenotypic consequences of gene loss and to investigate compensatory mechanisms activated in response to the absence of RHBG. Researchers utilize these models in various assays, including transport studies, signaling pathway analyses, and drug response evaluations, thereby providing insights into how alterations in RHBG expression may influence pathologies such as metabolic disorders or kidney function abnormalities.

The scientific importance of these knockout cell lines is evident in their broad applications in both fundamental research and clinical investigations. They allow for the exploration of genetic contributions to diseases and serve as a preliminary platform for developing therapeutic strategies, including targeted gene therapies and pharmacological interventions.

What sets RHBG Gene Knockout Cell Lines apart from alternative models is their precise gene targeting, ensuring that the resultant cell lines exhibit a clean knockout without off-target effects. This specificity enhances the reliability of experimental results while reducing the need for extensive validation studies that are often required with less rigorously characterized models.

For researchers and clinicians, the value of using RHBG Gene Knockout Cell Lines lies in their ability to generate reproducible and interpretable data that can propel scientific inquiry towards clinical applications. Their use may accelerate advancements in understanding disease mechanisms, ultimately informing the development of novel therapeutic strategies.

At our company, we pride ourselves on our unwavering commitment to excellence in biotechnology and cell line development. Our expertise and dedication to quality ensure that our RHBG Gene Knockout Cell Lines meet the highest standards, providing researchers with reliable tools for their impactful investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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