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RHBDL2 Knockout Cell Lines

Gene: RHBDL2

Official Full Name: rhomboid like 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22058 RHBDL2 Knockout cell line (HeLa) Human RHBDL2 1:3~1:6 Negative Online Inquiry
KO22059 RHBDL2 Knockout cell line (A549) Human RHBDL2 1:3~1:4 Negative Online Inquiry

Background

RHBDL2 Gene Knockout Cell Lines are specially engineered cells that have undergone targeted genomic modification to inactivate the RHBDL2 gene, which encodes for a rhomboid-like protein involved in proteolytic processes within cellular membranes. These knockout cell lines serve as a crucial model for studying the biochemical pathways and physiological roles associated with RHBDL2, particularly in disease progression and cellular signaling.

The key function of RHBDL2 involves regulating the activity of membrane-anchored proteins through intramembrane proteolysis. By knocking out this gene, researchers can examine the downstream effects on cell membrane dynamics, protein interactions, and the broader implications on cellular homeostasis. Utilizing these knockout cell lines allows researchers to dissect the molecular mechanisms underlying various cellular processes and to elucidate the role of RHBDL2 in conditions such as cancer and neurodegeneration.

The scientific importance of RHBDL2 Gene Knockout Cell Lines extends into clinical applications, where they serve as a valuable tool for drug discovery and therapeutic interventions. By assessing how the absence of RHBDL2 influences the effects of pharmacological agents, scientists can better understand potential treatment avenues and identify novel targets for therapeutic development.

What sets our RHBDL2 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility, ensuring that experimental results are robust and translatable. The lines are developed using advanced CRISPR/Cas9 gene editing technology, providing researchers with accurate and efficient modifications. Furthermore, our extensive characterization of these cell lines guarantees their suitability for a wide range of experimental applications, from basic research to translational studies.

Investing in RHBDL2 Gene Knockout Cell Lines represents a valuable opportunity for researchers and clinicians seeking innovative solutions to complex biological questions. With our commitment to scientific excellence and a portfolio of high-quality biological products, we are dedicated to supporting advancements in research and healthcare through reliable and effective tools tailored to the needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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