Gene: RGS10
Official Full Name: regulator of G protein signaling 10provided by HGNC
Gene Summary: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35633 | RGS10 Knockout cell line (HeLa) | Human | RGS10 | 1:3~1:6 | Negative | Online Inquiry |
KO35634 | RGS10 Knockout cell line (HCT 116) | Human | RGS10 | 1:2~1:4 | Negative | Online Inquiry |
KO35635 | RGS10 Knockout cell line (HEK293) | Human | RGS10 | 1:3~1:6 | Negative | Online Inquiry |
KO35636 | RGS10 Knockout cell line (A549) | Human | RGS10 | 1:3~1:4 | Negative | Online Inquiry |
RGS10 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the RGS10 (Regulator of G protein signaling 10) gene in various biological contexts. By employing precise gene-editing technologies, these cell lines have been engineered to disrupt the expression of the RGS10 gene, thereby enabling researchers to explore the functional implications of RGS10 in G protein signaling and its associated pathways.
The primary function of RGS10 involves the modulation of G protein-coupled receptor (GPCR) signaling, acting as a GTPase-activating protein that accelerates the inactivation of G proteins. In cellular systems, the knockout of RGS10 can elucidate its roles in signal transduction and its impact on physiological processes such as immune response, neurodevelopment, and cardiac functions. Furthermore, these cell lines serve as an invaluable tool in studying diseases related to RGS10 dysregulation, including certain cancers and neurological disorders.
The scientific importance of RGS10 Gene Knockout Cell Lines is underscored by their potential applications in both fundamental research and therapeutic development. By allowing the investigation of RGS10’s role in signaling pathways, researchers can better understand its contributions to cellular behavior, providing insights that may lead to novel treatment strategies for diseases in which this gene plays a critical role.
What sets our RGS10 Gene Knockout Cell Lines apart is the precision and reliability of our gene-editing techniques, coupled with comprehensive validation procedures that confirm the absence of the target gene. Unlike competing products that may offer non-specific knockouts or limited functional validation, our cell lines provide a robust, reliable platform for experimental reproducibility.
For researchers and clinicians looking to advance their understanding of G protein signaling or explore novel therapeutic targets, RGS10 Gene Knockout Cell Lines represent an indispensable resource. By integrating cutting-edge technology with a commitment to rigorous scientific standards, we enable our partners to accelerate their discoveries. Our company prides itself on delivering high-quality biological products and unwavering support, making us a trusted leader in the field of genetic research tools.
Please note that all services are for research use only. Not intended for any clinical use.
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