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RGL1 Knockout Cell Lines

Gene: RGL1

Official Full Name: ral guanine nucleotide dissociation stimulator like 1provided by HGNC

Gene Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08920 RGL1 Knockout cell line (HeLa) Human RGL1 1:3~1:6 Negative Online Inquiry
KO08921 RGL1 Knockout cell line (HCT 116) Human RGL1 1:2~1:4 Negative Online Inquiry
KO08922 RGL1 Knockout cell line (HEK293) Human RGL1 1:3~1:6 Negative Online Inquiry
KO08923 RGL1 Knockout cell line (A549) Human RGL1 1:3~1:4 Negative Online Inquiry

Background

RGL1 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the investigation of RGL1 function and its role in various biological processes. RGL1, or Rho GTPase-activating protein 1, is implicated in cellular signaling pathways that regulate cell proliferation, differentiation, and migration. The knockout of the RGL1 gene allows researchers to dissect its contributions in pathophysiology, particularly in relation to cancer, neurodegenerative disorders, and metabolic diseases.

These cell lines utilize CRISPR-Cas9 technology to precisely edit the genomic sequence, resulting in a complete knockout of the RGL1 gene. This mechanistic approach ensures that the resultant cell lines are not only devoid of the RGL1 protein but also possess stable genomic integration, which enhances reproducibility in experimental outcomes. By eliminating this key regulatory protein, researchers can assess the downstream effects on signaling pathways and cellular behavior, thus gaining insights that are crucial for understanding disease mechanisms.

The scientific importance of RGL1 Gene Knockout Cell Lines is underscored by their broad applications in pharmacological research, genetic studies, and biomarker discovery. These models enable innovative approaches to drug screening, allowing for the identification of novel therapeutic candidates that target specific cellular mechanisms altered in RGL1-deficient cells. Moreover, they serve as vital tools in translational research, providing a framework for further explorations into gene function and interaction within the cellular milieu.

One of the unique selling points of our RGL1 Gene Knockout Cell Lines is their robust validation and quality assurance, setting them apart from alternative gene-editing solutions. The high specificity and efficiency of the CRISPR-Cas9 methodology ensure minimal off-target effects, offering researchers confidence in the integrity of their data.

The value of these cell lines lies in their capability to advance our understanding of RGL1 in various biological contexts, thereby opening new avenues for innovative therapies. Researchers, clinicians, and biotechnologists will find this product invaluable in pursuing experimental objectives that require precise modulation of gene function.

With a strong foundation in genetic engineering and cell line development, our company is committed to providing researchers with high-quality biological tools tailored to enhance scientific discovery and clinical breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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