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RELB Knockout Cell Lines

Gene: RELB

Official Full Name: RELB proto-oncogene, NF-kB subunitprovided by HGNC

Gene Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11000 RELB Knockout cell line (HeLa) Human RELB 1:3~1:6 Negative Online Inquiry
KO11001 RELB Knockout cell line (HCT 116) Human RELB 1:2~1:4 Negative Online Inquiry
KO11002 RELB Knockout cell line (HEK293) Human RELB 1:3~1:6 Negative Online Inquiry
KO11003 RELB Knockout cell line (A549) Human RELB 1:3~1:4 Negative Online Inquiry

Background

RELB Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the function of the RELB gene, which plays a crucial role in the regulation of inflammatory responses and immune system signaling. By employing the CRISPR-Cas9 technology, these cell lines have been rendered incapable of expressing the RELB protein, enabling researchers to observe the biological consequences of its absence in a controlled environment.

The primary function of RELB Gene Knockout Cell Lines lies in their ability to provide insights into the molecular pathways influenced by RELB, particularly in relation to NF-κB signaling. The knockout model allows for a deeper understanding of how RELB contributes to various physiological and pathological processes, including immune response modulation, cell survival, and tumorigenesis. The mechanistic studies facilitated by these cell lines are vital in exploring novel therapeutic strategies targeting RELB-driven pathways in diseases such as cancer and autoimmune disorders.

The scientific importance of RELB Gene Knockout Cell Lines extends into both research and clinical settings. Researchers can utilize these cell lines to investigate the complex interactions within the immune microenvironment and assess potential drug candidates. Additionally, studying RELB-related gene networks aids in the identification of biomarkers for disease progression and treatment response, contributing to personalized medicine frameworks.

One of the significant advantages of our RELB Gene Knockout Cell Lines is their high specificity and reproducibility compared to alternative models. Conventional methods of gene knockout often result in off-target effects or incomplete knockout efficiencies; however, the precision of CRISPR technology ensures that the RELB deletion is both effective and consistent across different cell batches. Furthermore, these cell lines have been validated in multiple assays, establishing their reliability for experimental reproducibility.

For researchers, clinicians, and biopharmaceutical companies, the RELB Gene Knockout Cell Lines present a valuable tool for advancing biomedical discoveries. Their ability to facilitate the exploration of the RELB gene’s role in health and disease offers opportunities for innovation in therapeutic development and enhances our understanding of immune system dynamics.

Our company specializes in cutting-edge genetic products and has a robust background in gene editing technologies and customized cell lines. With an unwavering commitment to enhancing research outcomes, we aim to provide exemplary tools that empower the scientific community to drive forward the frontiers of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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