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RECQL4 Knockout Cell Lines

Gene: RECQL4

Official Full Name: RecQ like helicase 4provided by HGNC

Gene Summary: The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33266 RECQL4 Knockout cell line (HeLa) Human RECQL4 1:3~1:6 Negative Online Inquiry
KO33267 RECQL4 Knockout cell line (HCT 116) Human RECQL4 1:2~1:4 Negative Online Inquiry
KO33268 RECQL4 Knockout cell line (HEK293) Human RECQL4 1:3~1:6 Negative Online Inquiry
KO33269 RECQL4 Knockout cell line (A549) Human RECQL4 1:3~1:4 Negative Online Inquiry

Background

RECQL4 Gene Knockout Cell Lines are specialized cell lines developed for targeted investigations into the biological role of the RECQL4 gene, which encodes a crucial DNA helicase involved in maintaining genomic stability. By implementing CRISPR/Cas9 technology, these cell lines have been precisely engineered to lack the functional RECCQ4 gene, allowing researchers to dissect its involvement in processes such as DNA replication, repair, and cellular aging.

The mechanism underlying these cell lines involves the targeted disruption of the RECQL4 gene, which enables scientists to observe the effects of its absence. The resulting phenotypic changes in cellular behavior, such as increased sensitivity to DNA-damaging agents or altered cell cycle progression, provide critical insights into the gene's role in cancer biology and other diseases. Researchers utilize RECQL4 Gene Knockout Cell Lines to better understand the mechanisms of hereditary diseases, particularly those linked to defects in DNA repair pathways.

One of the key advantages of using RECQL4 Gene Knockout Cell Lines is their potential for high specificity in experimental designs. Unlike other models that may present confounding genetic backgrounds, these cell lines allow for uniformity and reproducibility in experiments, yielding clearer, more conclusive data. Additionally, they can streamline the initial stages of drug testing, providing a superior platform compared to traditional whole-animal models with complex physiological variables.

For researchers and clinicians engaged in genomic research or therapeutic development, having access to such precise genetic models is invaluable. They provide essential tools for hypothesis testing and validation, ultimately leading to advances in targeted therapies and personalized medicine.

As a company committed to innovation and scientific advancement, we leverage cutting-edge techniques to deliver high-quality biological products. Our RECQL4 Gene Knockout Cell Lines exemplify our dedication to supporting the research community with reliable tools for critical discoveries in genetics and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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