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RDH11 Knockout Cell Lines

Gene: RDH11

Official Full Name: retinol dehydrogenase 11provided by HGNC

Gene Summary: Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde and retinoid metabolic process. Acts upstream of or within retinal metabolic process. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23002 RDH11 Knockout cell line (HeLa) Human RDH11 1:3~1:6 Negative Online Inquiry
KO23003 RDH11 Knockout cell line (HCT 116) Human RDH11 1:2~1:4 Negative Online Inquiry
KO23004 RDH11 Knockout cell line (HEK293) Human RDH11 1:3~1:6 Negative Online Inquiry
KO23005 RDH11 Knockout cell line (A549) Human RDH11 1:3~1:4 Negative Online Inquiry

Background

RDH11 Gene Knockout Cell Lines are specially engineered cellular models designed to provide researchers with a powerful tool for studying the biological functions of the RDH11 gene, which encodes a retinol dehydrogenase involved in retinoid metabolism. By utilizing CRISPR-Cas9 technology, these cell lines feature precise disruptions of the RDH11 gene, allowing for in-depth exploration of its role in various metabolic pathways, cellular signaling, and its implications in disease states, such as cancer and metabolic disorders.

Key functions of the RDH11 Gene Knockout Cell Lines include the ability to model the loss-of-function effects of RDH11 in a controlled environment. Researchers can investigate how the absence of RDH11 impacts cellular processes such as oxidative stress response, differentiation, and proliferation. Understanding these mechanisms is crucial for uncovering the gene's involvement in pathophysiological conditions, thereby informing targeted therapeutic strategies.

The scientific importance of these knockout cell lines extends to both basic and applied research settings. They enable studies aimed at elucidating the role of retinoid signaling in development and disease, providing insight into potential interventions. In clinical applications, understanding RDH11 functions may lead to advances in pharmacotherapy for conditions linked to retinoid metabolism.

Compared to traditional cell lines or models, RDH11 Gene Knockout Cell Lines offer unique advantages, including specificity, reproducibility, and the ability to conduct high-throughput screening for potential drug candidates. Additionally, they facilitate the investigation of gene interactions and compensation mechanisms that may occur in native systems.

This product is invaluable for researchers and clinicians aiming to deepen their understanding of retinol metabolism and its implications in health and disease. By choosing RDH11 Gene Knockout Cell Lines, scientists can enhance the rigor of their studies while contributing to the advancement of biomedical research.

Leveraging decades of expertise in genetic engineering and cellular biology, our company is dedicated to providing innovative biological products that empower research excellence and pave the way for novel therapeutic discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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