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RCBTB1 Knockout Cell Lines

Gene: RCBTB1

Official Full Name: RCC1 and BTB domain containing protein 1provided by HGNC

Gene Summary: This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20549 RCBTB1 Knockout cell line (HeLa) Human RCBTB1 1:3~1:6 Negative Online Inquiry
KO20550 RCBTB1 Knockout cell line (HCT 116) Human RCBTB1 1:2~1:4 Negative Online Inquiry
KO20551 RCBTB1 Knockout cell line (HEK293) Human RCBTB1 1:3~1:6 Negative Online Inquiry
KO20552 RCBTB1 Knockout cell line (A549) Human RCBTB1 1:3~1:4 Negative Online Inquiry

Background

RCBTB1 Gene Knockout Cell Lines are engineered cellular models designed to facilitate the study of the RCBTB1 gene's function and its role in various biological processes. Utilizing CRISPR-Cas9 gene-editing technology, these knockout cell lines enable researchers to precisely deactivate the RCBTB1 gene, allowing for a comprehensive analysis of its contributions to cellular pathways and disease mechanisms.

The primary function of RCBTB1 gene knockout cell lines is to provide insights into the gene's involvement in key biological processes such as cellular signaling, proliferation, and differentiation. By eliminating the expression of RCBTB1, researchers can observe resultant phenotypic changes and gene expression alterations, leading to a deeper understanding of its biological roles and implications in cancer research, neurodegenerative diseases, and other pathologies.

The scientific importance of these cell lines extends to various applications in both basic research and translational studies. They serve as invaluable tools for drug discovery, functional genomics, and the validation of therapeutic targets, contributing to advancements in precision medicine. RCBTB1 knockout models can also be utilized to better understand genetic interactions and compensatory mechanisms, thereby enhancing the breadth of therapeutic approaches in clinical settings.

Compared to traditional cell models, RCBTB1 gene knockout cell lines provide significant advantages. They are characterized by high specificity and efficiency in gene disruption, thus reducing off-target effects that can confound experimental outcomes. Furthermore, they can be easily integrated into existing workflows, allowing for seamless application in diverse experimental contexts.

For researchers and clinicians, RCBTB1 Gene Knockout Cell Lines represent a powerful resource for elucidating gene function, exploring disease etiology, and accelerating the laboratory-to-clinic pipeline. Our company specializes in the development of high-quality, reliable biological products, and our commitment to excellence ensures that you receive only the best tools for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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