Gene: RBP4
Official Full Name: retinol binding protein 4provided by HGNC
Gene Summary: This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35667 | RBP4 Knockout cell line (A549) | Human | RBP4 | 1:3~1:4 | Negative | Online Inquiry |
RBP4 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the RBP4 gene, which encodes Retinol-Binding Protein 4. This protein is a crucial player in the transport of retinol (vitamin A) from the liver to peripheral tissues, thus influencing various metabolic and physiological processes, including lipid metabolism, insulin sensitivity, and cellular growth regulation. The RBP4 gene knockout is achieved using advanced CRISPR/Cas9 technology, which allows for precise edits in the genome, ensuring reliable and reproducible knockout efficiency.
These cell lines serve multiple key functions in research, particularly in elucidating the role of RBP4 in metabolic disorders and other pathophysiological conditions. By studying these knockout models, researchers can investigate the implications of RBP4 absence on energy homeostasis, as well as developmental biology and disease pathways related to obesity, diabetes, and cardiovascular health. Furthermore, the ability to manipulate and analyze these cell lines in both in vitro and in vivo models enhances their relevance in therapeutic research and pharmacological studies.
The scientific importance of RBP4 Gene Knockout Cell Lines is underscored by their potential applications in developing targeted therapies. They offer a unique platform for screening compounds that may modulate RBP4-related pathways, providing invaluable insights into drug discovery processes. Compared to traditional cell lines, these knockout models offer enhanced specificity and clarity in interpreting experimental outcomes, reducing the risk of confounding effects common in other models that retain RBP4 expression.
Moreover, the competitive edge of our RBP4 Gene Knockout Cell Lines lies in their rigorous quality control measures and validation processes, which ensure high consistency and performance. By selecting these exceptional cell lines, researchers and clinicians benefit from enhanced reproducibility and experimental reliability, critical for advancing their studies and translating findings into clinical applications.
At [Your Company Name], we pride ourselves on our expertise in providing advanced biological products that aid significant research and clinical outcomes. Our commitment to innovation and quality ensures that our offerings, including the RBP4 Gene Knockout Cell Lines, empower scientists and healthcare professionals to reach new heights in their investigational endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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