Home / RASSF8 Knockout Cell Lines

RASSF8 Knockout Cell Lines

Gene: RASSF8

Official Full Name: Ras association domain family member 8provided by HGNC

Gene Summary: This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14691 RASSF8 Knockout cell line (HeLa) Human RASSF8 1:3~1:6 Negative Online Inquiry
KO14692 RASSF8 Knockout cell line (HCT 116) Human RASSF8 1:2~1:4 Negative Online Inquiry
KO14693 RASSF8 Knockout cell line (HEK293) Human RASSF8 1:3~1:6 Negative Online Inquiry
KO14694 RASSF8 Knockout cell line (A549) Human RASSF8 1:3~1:4 Negative Online Inquiry

Background

RASSF8 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to deactivate the RASSF8 gene, a critical component in the regulation of cellular processes, particularly those related to cancer progression and metastasis. These cell lines provide a unique platform for studying the molecular mechanisms underlying RASSF8 function and its role in tumor biology.

The key function of RASSF8 involves its participation in the regulation of the RAS signaling pathway, which influences cell proliferation and survival. In knockout models, the absence of RASSF8 allows researchers to observe the downstream effects on cell cycle progression, apoptosis, and oncogenic signaling pathways. This elucidation can lead to a deeper understanding of cancer biology and potential therapeutic targets related to RASSF8's function.

The scientific importance of RASSF8 Gene Knockout Cell Lines extends into both research and clinical applications. These models can be employed in high-throughput screening for drug discovery, examining how the loss of RASSF8 affects cellular responses to various chemotherapeutic agents. Furthermore, they enable investigations into stem cell differentiation and tumor microenvironment interactions, broadening the potential impact of RASSF8 research beyond oncology.

Compared to alternatives like conventional wild-type cell lines, RASSF8 knockout models provide a focused approach to study the specific biological functions attributable to RASSF8 without the confounding influence of normal gene expression. This specificity enhances experimental accuracy and can significantly improve the relevance of findings in translational research.

For researchers and clinicians, these cell lines are invaluable tools that streamline experiments aimed at uncovering the roles of oncogenes and tumor suppressor genes, ultimately driving forward the frontier of personalized medicine and targeted therapies. The ability to manipulate specific genetic pathways enables a refined approach to understanding complex disease mechanisms.

Our company, backed by expertise in genetic engineering and cell line development, is dedicated to providing innovative biological products that enable groundbreaking research in cancer biology and beyond. With RASSF8 Gene Knockout Cell Lines, we equip scientists with the tools they need to push beyond traditional boundaries in their quest for new therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.